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http://dx.doi.org/10.7845/kjm.2018.8073

Suppression of metastasis-related ERBB2 and PLAU expressions in human breast cancer MCF 7 cells by fermented soybean extract  

Park, Jameon (Department of Biotechnology, Hoseo University)
Kim, Han Bok (Department of Biotechnology, Hoseo University)
Publication Information
Korean Journal of Microbiology / v.54, no.4, 2018 , pp. 320-324 More about this Journal
Abstract
Chunkookjang, fermented soybean is rich in diverse oligopeptides which derived from cleavage of soybean proteins during fermentation. Microarray data containing differently expressed genes in breast cancer cells treated with fermented soybean extract and well known breast cancer metastasis markers were combined, and a new network was constructed. It is used to check interactions between the marker proteins and the differently expressed genes. Based on the network analysis, PLAU (plasminogen activator, urokinase, uPA) and ERBB2 (epidermal growth factor receptor 2) are chosen as possible metastasis genes. We treated breast cancer MCF7 cells with fermented soybean extract and measured expression levels of PLAU and ERBB2. Fermented soybean extract suppressed PLAU and ERBB2 expressions conspicuously. In the cancer cells treated with fermented soybean extracts, an inflammation marker, NO production was also reduced. It will be interesting to find specific peptides to suppress PLAU and ERBB2 expressions in human breast cancer cells.
Keywords
ERBB2; PLAU; breast cancer; fermented soybean extract; metastasis; network analysis;
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