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http://dx.doi.org/10.7845/kjm.2018.8010

Draft genome sequence of lytic bacteriophage KP1 infecting bacterial pathogen Klebsiella pneumoniae  

Kim, Youngju (Optipharm Inc.)
Bang, Ina (Department of Genetic Engineering and Graduate School of Biotechnology, College of Life Sciences, Kyung Hee University)
Yeon, Young Eun (Optipharm Inc.)
Park, Joon Young (Department of Genetic Engineering and Graduate School of Biotechnology, College of Life Sciences, Kyung Hee University)
Han, Beom Ku (Optipharm Inc.)
Kim, Hyunil (Optipharm Inc.)
Kim, Donghyuk (Department of Genetic Engineering and Graduate School of Biotechnology, College of Life Sciences, Kyung Hee University)
Publication Information
Korean Journal of Microbiology / v.54, no.2, 2018 , pp. 152-154 More about this Journal
Abstract
Klebsiella pneumoniae is a Gram-negative, rod-shape bacterium causing disease in human and animal lungs. K. pneumoniae has been often found to gain antimicrobial resistance, thus it has been difficult to treat K. pneumoniae infection with antibiotics. For such infection, bacteriophage can provide an alternative approach for pathogenic bacterial infection with antimicrobial resistance, because of its sensitivity and specificity to the host bacteria. Bacteriophage KP1 was isolated in sewage and showed specific infectivity to K. pneumoniae. Here, we report the draft genome sequence of Klebsiella pneumoniae phage KP1. The draft genome of KP1 is 167,989 bp long, and the G + C content is 39.6%. The genome has 295 predicted ORFs and 14 tRNA genes. In addition, it encodes various enzymes which involve in lysis of the host cell such as lysozyme and holin.
Keywords
Klebsiella pneumoniae; bacteriophage; draft genome sequence; Illumina Hiseq;
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