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http://dx.doi.org/10.7845/kjm.2018.7092

Cnestis palala (Lour.) Merr. extract suppresses Propionibacterium acnes-induced inflammation  

Shin, Jin Hak (Department of Molecular Bioscience, College of Biomedical Science, Institute of Bioscience & Biotechnology, Kangwon National University)
Lee, Eun Hye (Department of Molecular Bioscience, College of Biomedical Science, Institute of Bioscience & Biotechnology, Kangwon National University)
Kim, Seon Sook (Department of Molecular Bioscience, College of Biomedical Science, Institute of Bioscience & Biotechnology, Kangwon National University)
Sydara, Kongmany (Minstry of Health, Institute of Traditional Medicine)
Seo, Su Ryeon (Department of Molecular Bioscience, College of Biomedical Science, Institute of Bioscience & Biotechnology, Kangwon National University)
Publication Information
Korean Journal of Microbiology / v.54, no.1, 2018 , pp. 38-45 More about this Journal
Abstract
Acne is an inflammatory skin disease that occurs in puberty and young people. Propionibacterium acnes (P. acnes) is known to be a major cause of inflammation in acne. P. acnes proliferates within hair follicles blocked by overproduced sebum in the skin, and thereby activates monocytic cells to promote the secretion of pro-inflammatory cytokines. In this study, we investigated the possibility of Cnestis palala (Lour.) Merr. extract to diminish P. acnes-mediated inflammatory responses. We found that C. palala extract significantly attenuated P. acnes-induced pro-inflammatory cytokine expressions, such as $IL-1{\beta}$, IL-6, $TNF-{\alpha}$, iNOS, and COX-2 in mouse macrophage RAW264.7 cells. Moreover, we observed that C. palala extract inhibited $NF-{\kappa}B$ transcriptional activation, which is the major transcription factor of inflammatory cytokine expression. Therefore, it is expected that C. palala extract has a potential as a therapeutic agent or supplement for the treatment P. acnes-induced inflammatory responses.
Keywords
Propionibacterium acnes; Cnestis palala (Lour.) Merr.; inflammation; pro-inflammatory cytokine;
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