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http://dx.doi.org/10.7845/kjm.2018.7031

Molecular epidemiological study of norovirus gastroenteritis outbreaks in Gyeonggi-Do from 2014 to 2015  

Nam, Soo-Jung (Team of virus, Gyeonggi Institute of Health and Environment)
Park, Po-Hyun (Team of virus, Gyeonggi Institute of Health and Environment)
Bang, Sun-Jae (Team of virus, Gyeonggi Institute of Health and Environment)
Huh, Jeong-Weon (Team of virus, Gyeonggi Institute of Health and Environment)
Yun, Hee-Jeong (Team of virus, Gyeonggi Institute of Health and Environment)
Park, Kwang-Hee (Team of virus, Gyeonggi Institute of Health and Environment)
Yoon, Mi-Hye (Team of virus, Gyeonggi Institute of Health and Environment)
Publication Information
Korean Journal of Microbiology / v.54, no.1, 2018 , pp. 24-30 More about this Journal
Abstract
Norovirus infection is a leading cause of nonbacterial gastroenteritis outbreaks. New variants of GII.4 have emerged approximately every 2~3 years and have caused norovirus gastroenteritis pandemics globally. In this study, analysis and molecular genetic characteristics of the norovirus gastroenteritis outbreaks 2,917 samples in Gyeonggi-Do from 2014 to 2015. As a result, 247 samples out of 2,917 samples are positive for norovirus. Norovirus molecular genetic characteristics of the GI 8 types (GI-1, 2, 3, 4, 5, 6, 12, 14), GII 10 types (GII - 2, 3, 4, 5, 6, 11, 12, 14, 16, 17). Genome sequences of isolated noroviruses were similar to those of new GII.17 Kawasaki 2014 variants with 96.6 identity, suggesting that these viruses were imported from overseas. 44% of virus incidence was originated from school meal service. Therefore, a continuous monitoring and school sanitation should be required for preventing a massive virus outbreak.
Keywords
genotype; norovirus; outbreak; variant;
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1 Lu, J., Sun, L., Fang, L., Yang, F., Mo, Y., Lao, J., Zheng, H., Tan, X., Lin, H., Rutherford, S., et al. 2015. Gastroenteritis outbreaks caused by norovirus GII.17, Guangdong Province, China, 2014-2015. Emerg. Infect. Dis. 21, 1240-1242.   DOI
2 Matsushima, Y., Ishikawa, M., Shimizu, T., Komane, A., Kasuo, S., Shinohara, M., Nagasawa, K., Kimura, H., Ryo, A., Okabe, N., et al. 2015. Genetic analyses of GII.17 norovirus strains in diarrheal disease outbreaks from December 2014 to March 2015 in Japan reveal a novel polymerase sequence and amino acid substitutions in the capsid region. Euro Surveill. 20, 2-7.
3 Noel, J.S., Fankhauser, R.L., Ando, T., Monroe, S.S., and Glass, R.I., 1999. Identification of a distinct common strain of "Norwalk-like viruses" having a global distribution. J. Infect. Dis. 179, 1334-1344.   DOI
4 Park, P.H., Park, M.K., Park, E.M., Cho, H.G., Lee, H.K., Yoon, M.H., and Lee, J.B. 2013. Molecular epidemiological study of norovirus-associated gastroenteritis outbreaks in Gyeonggi from 2011 to 2013; Emergence and spread of GII.4-2012 Sydney variants. Rep. Inst. Gyeonggi-Do Health & Environment 26, 23-35.
5 Teunis, P.F., Moe, C.L., Liu, P., Miller, S.E., Lindesmith, L., and Baric, R.S., 2008. Norwalk virus: how infectious is it? J. Med. Virol. 80, 1468-1476.   DOI
6 Thorne, L.G. and Goodfellow, I.G. 2014. Norovirus gene expression and replication. J. Gen. Virol. 95, 278-291.   DOI
7 Vinje J. 2015. Advances in laboratory methods for detection and typing of norovirus. J. Clin. Microbiol. 53, 373-381.   DOI
8 Gao, Z., Liu, B., Huo, D., Yan, H., Jia, L., Du, Y., Qian, H., Yang, Y., Wang, X., Li, J., et al. 2015. Increased norovirus activity was associated with a novel norovirus GII.17 variant in Beijing, China during winter 2014-2015. BMC Infect. Dis. 15, 574.   DOI
9 Bartsch, S.M., Lopman, B.A., Ozawa, S., Hall, A.J., and Lee, B.Y. 2016. Global economic burden of norovirus gastroenteritis. PLoS One 11, e0151219.   DOI
10 de Graaf, M., van Beek, J., Vennema, H., Podkolzin, A.T., Hewitt, J., Bucardo, F., Templeton, K., Mans, J., Nordgren, J., Reuter, G., et al. 2015. Emergence of a novel GII.17 norovirus-End of the GII.4 era? Euro Surveil. 20, 1-8.
11 Kim, E.J., Kim, M.S., Chae, Y.Z., and Cheon, D.S. 2012. Prevalence of human noroviruses detected from outbreaks of gastroenteritis patients in Seoul, Korea. Korean J. Microbiol. 48, 102-108.   DOI
12 Ko, E.M., Seok, W.S., Lee, T.J., Im, E.J., and Son, S.Y. 2008. Epidemiological characteristics of gastroenteritis outbreaks by norovirus in Gangwon-do 2007. Rep. Inst. Kang-won Health & Environment 19, 30-40.
13 Lu, J., Fang, L., Zheng, H., Lao, J., Yang, F., Sun, L., Xiao, J., Lin, J., Song, T., Ni, T., et al. 2016. The evolution and transmission of epidemic GII.17 noroviruses. J. Infect. Dis. 214, 556-564.
14 Kroneman, A., Vega, E., Vennema, H., Vinje, J., White, P.A., Hansman, G., Green, K., Martella, V., Katayama, K., and Koopmans, M. 2013. Proposal for a unified norovirus nomenclature and genotyping. Arch. Virol. 158, 2059-2068.   DOI
15 Ku, P.T., Kim, N.H., Hwang, S.J., Park, D.J., and Lee, M.O. 2014. Epidemic patterns and molecular genetic analysis of diarrheacausing viruses related to food-borne illness in Busan. Rep. Inst. Busan Metropolitan city Health & Environment. 24, 9-18.