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http://dx.doi.org/10.7845/kjm.2016.6036

Reduction of TNFα expression by Chungkookjang extracts in human breast cancer MDA-MB-231 cells  

Park, Jameon (Department of Biotechnology, The Research Institute for Basic Sciences, Hoseo University)
Kang, Choong Kyung (Department of Nanobiotronics, Hoseo University)
Kim, Han Bok (Department of Biotechnology, The Research Institute for Basic Sciences, Hoseo University)
Publication Information
Korean Journal of Microbiology / v.52, no.3, 2016 , pp. 380-382 More about this Journal
Abstract
Chungkookjang, fermented soybeans, contains diverse peptides produced during fermentation. Fermented soybean extracts containing the peptides can affect cellular signal transduction. Proliferation of human breast cancer MDA-MB-231 cells were repressed dependent on concentrations of fermented soybean extracts. Since fermented soybean extracts inhibited breast cancer cell's growth, and inflammation is related to cancer, it is determined whether it can suppress inflammatory $TNF{\alpha}$ expression. $TNF{\alpha}$ expression in MDA-MB 231 cells treated with fermented soybean extracts was repressed by that extracts. $TNF{\alpha}$ inhibitors were developed as drugs for autoimmune diseases. Since fermented soybean extracts suppressed $TNF{\alpha}$ expression, it can be developed as those drugs.
Keywords
breast cancer; fermented soybean; inflammation; $TNF{\alpha}$;
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Times Cited By KSCI : 4  (Citation Analysis)
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