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http://dx.doi.org/10.7845/kjm.2016.6033

Anti-multi drug resistant pathogen activity of siderochelin A, produced by a novel Amycolatopsis sp. KCTC 29142  

Lee, Dong-Ryung (Center for Nutraceutical and Pharmaceutical Materials Myongji University)
Cheng, Jinhua (Center for Nutraceutical and Pharmaceutical Materials Myongji University)
Lee, Sung-Kwon (Center for Nutraceutical and Pharmaceutical Materials Myongji University)
Hong, Hee-Jeon (Department of Biological and Medical Sciences, Faculty of Health and Life Sciences, Oxford Brookes University)
Song, Jaekyeong (Division of Agricultural Microbiology, National Academy of Agricultural Science, Rural Development Administration)
Yang, Seung Hwan (Department of Biotechnology, Chonnam National University)
Suh, Joo-Won (Center for Nutraceutical and Pharmaceutical Materials Myongji University)
Publication Information
Korean Journal of Microbiology / v.52, no.3, 2016 , pp. 327-335 More about this Journal
Abstract
A novel Amycolatopsis strain KCTC 29142 was isolated and characterized based on the polyphasic taxonomic analysis including morphological observation, phylogenetic analysis, physiological and chemotaxonomic characteristics. The ethyl acetate extract of strain KCTC 29142 culture broth showed strong antibacterial activity and the active compound was identified as siderochelin A, a ferrous-ion chelating compound. In this study, siderochelin A showed good activity against multi-drug resistant pathogens, including Acinetobacter baumanii, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Staphylococcus aureus (VRSA), and Escherichia coli (E. coli). The minimum inhibitory activity against clinical isolates was also determined.
Keywords
Amycolatopsis; antibacterial activity; anti-multi drug resistant pathogens; Siderochelin A;
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