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http://dx.doi.org/10.7845/kjm.2015.5062

Inhibitory effect of SeO2 on cell growth of methicillin-resistant Staphylococcus aureus  

Han, Yeong-Hwan (Department of Medical Biotechnology, Dongguk University)
Publication Information
Korean Journal of Microbiology / v.51, no.4, 2015 , pp. 444-447 More about this Journal
Abstract
This study was carried out to determine the antibacterial activity of $SeO_2$ against pathogenic bacteria, methicillin-resistant Staphylococcus aureus (MRSA). Using the disc diffusion method, $SeO_2$ showed higher antibacterial activity against Gram-positive bacteria than Gram-negative bacteria used in this study. Coccus-form bacteria showed much susceptible to $SeO_2$, compared to bacillus-form bacteria. Compared to antibiotics-susceptible S. aureus, antibiotics used in this study showed lower antibacterial activity against MRSA. As $200-500{\mu}g/disc$ of $SeO_2$ was applied, diameters of clear zone for S. aureus and MRSA were 20-32.7 mm and 13.5-17.9 mm, respectively. For MRSA, minimal inhibitory concentration of $SeO_2$ was $40{\mu}g/ml$. When $SeO_2$ was added in culture broth, cell growth of MRSA was inhibited. These results will be applied to determine antibacterial mechanism of MRSA and other pathogenic microorganisms.
Keywords
Staphylococcus aureus; inhibitory effect; methicillin resistant; MIC; $SeO_2$;
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Times Cited By KSCI : 4  (Citation Analysis)
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