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http://dx.doi.org/10.7845/kjm.2015.5028

Peptide H reduces Il-6 expression in human breast cancer MDA-MB-231 cells  

Sung, Dae Il (Department of Biotechnology, The Research Institute for Basic Sciences, Hoseo University)
Park, Jameon (Department of Biotechnology, The Research Institute for Basic Sciences, Hoseo University)
Kang, Choong Kyung (Department of Nanobiotronics, Bioconvergence Lab, Hoseo University)
Kim, Han Bok (Department of Biotechnology, The Research Institute for Basic Sciences, Hoseo University)
Publication Information
Korean Journal of Microbiology / v.51, no.3, 2015 , pp. 308-311 More about this Journal
Abstract
Chungkookjang (fermented soybeans) contains diverse peptides. Human breast cancer MDA-MB-231 cells were treated with peptide H derived from Chungkookjang, and $TNF{\alpha}$ expression in the cells was conspicuously repressed, suggesting peptide H's regulation of IL6 since IL6 is induced by $TNF{\alpha}$. The structure of peptide H was different from those of glucocorticoid and dexamethasone, suggesting different mechanisms of $TNF{\alpha}$ expression suppression. Peptide H which reduces $TNF{\alpha}$ expression can be developed as drugs for cancer, rheumatoid arthritis and Crohn's disease, after more investigation.
Keywords
breast cancer; inflammation; peptide; $TNF{\alpha}$;
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