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http://dx.doi.org/10.7845/kjm.2014.4063

Upregulaton of Bradykinin Receptor Mediated by Nucleoside Diphosphate Kinase and Flagellin from Pseudomonas aeruginosa  

Kim, Yong-Jae (Department of Biotechnology and Bioinformatics, Korea University)
Shin, Hee-Sung (Department of Biotechnology and Bioinformatics, Korea University)
Jin, Shouguang (Department of Molecular Genetics and Microbiology, University of Florida)
Ha, Un-Hwan (Department of Biotechnology and Bioinformatics, Korea University)
Publication Information
Korean Journal of Microbiology / v.50, no.4, 2014 , pp. 281-284 More about this Journal
Abstract
Immune defense responses against Pseudomonas aeruginosa infection play an important role in maintaining homeostasis in the human body. Previously, we reported that expression of the bradykinin receptor (BR) is induced in response to P. aeruginosa infection. However, the factors responsible for the induction was uncertain. Here, we found that the type III secretion system (T3SS) is responsible for the induction of BR expression, and nucleoside diphosphate kinase (Ndk), as a novel T3SS effector, mediates the upregulation. The Ndk-mediated expression of BR was not induced by fliC mutant treatment, indicating the involvement of flagellin, one of the well-known pathogen-associated molecular patterns (PAMPs). Taken together, this study demonstrated that Ndk cooperates with flagella in the development of defense responses against P. aeruginosa infection.
Keywords
Pseudomonas aeruginosa; bradykinin receptor; flagellin; nucleoside diphosphate kinase;
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