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http://dx.doi.org/10.7845/kjm.2014.4048

Peptide H Reduces IL-6 Expression in Human Breast Cancer MDA-MB-231 Cells  

Sung, Dae Il (Department of Biotechnology, The Research Institute for Basic Sciences, Hoseo University)
Park, Jameon (Department of Biotechnology, The Research Institute for Basic Sciences, Hoseo University)
Kim, Han Bok (Department of Biotechnology, The Research Institute for Basic Sciences, Hoseo University)
Publication Information
Korean Journal of Microbiology / v.50, no.3, 2014 , pp. 261-263 More about this Journal
Abstract
Chronic inflammation is involved in cancers, rheumatoid arthritis, and Crohn's disease. Inerleukin-6 (IL-6) plays major roles in inflammation. Chungkookjang, fermented soybean contains diverse peptides produced by cleavage of soybean proteins. The peptides can be bioactive compounds. Peptide (Gly-Val-Tyr-Tyr-Met-Tyr was purified from Chungkookjang, and modified to be 6mer H, Glu-Val-Tyr-Tyr-Met-Tyr (EVYYMY). Peptide H's activity to suppress IL-6 expression in a human breast cancer cell, MDA-MB-231 was determined. IL-6 Expression was reduced in the cell treated with peptide H 25 times less than controls which were not treated with peptide H. Proliferation of MDA-MB-231 cells was inhibited by peptide H, which is concentration-dependent. Blocking of IL-6 signals is known to be effective in reducing inflammation in rheumatoid arthritis, Crohn's disease, and cancers. Since peptide H can reduce inflammatory IL-6 expression, application of this study will contribute to drug development for diseases which are caused by excessive IL-6.
Keywords
breast cancer; IL-6; inflammation; peptide;
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