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Conservation of the Epothilone-Biosynthetic Genes in Sorangium cellulosum Strains  

Hyun, Hye-Sook (Myxobacteria Bank, Department of Biotechnology, Hoseo University)
Youn, Jin-Kwon (Myxobacteria Bank, Department of Biotechnology, Hoseo University)
Cho, Kung-Yun (Myxobacteria Bank, Department of Biotechnology, Hoseo University)
Publication Information
Korean Journal of Microbiology / v.47, no.2, 2011 , pp. 170-173 More about this Journal
Abstract
The epothilone biosynthetic gene cluster (epoA~F, epoK) of Sorangium cellulosum KYC3013, an epothilone producing myxobacterium isolated in Korea, was cloned. When the amino acid sequences of the encoded proteins were compared with those from S. cellulosum SMP44, S. cellulosum So ce90, and S. cellulosum So0157-2, which were isolated in other continents or country, the proteins from different strains were 97.4-99.8% identical each other. This suggested that the epothilone-biosynthetic gene clusters are well conserved in S. cellulosum strains.
Keywords
Sorangium cellulosum; epothilone; epothilone biosynthetic gene; myxobacteria;
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