Construction and Analysis of a DNA Microarray for the Screening of Biosynthetic Genes of Secondary-Metabolites formation in Streptomyces
![]() |
Nam Soo Jung
(Department of Biological Science, Myongji University)
Kang Dae-Kyung (Bio-Resources Institute, Easy Bio System Inc.) Rhee Ki Hyeong (College of Industrial Science, Kongju National University) Kim Jong-Hee (Department of Biological Science, Myongji University) Kang Sang Sun (Division of Science Education, Chungbuk National University) Chang Yong Keun (Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology) Hong Soon-Kwang (Department of Biological Science, Myongji University) |
1 | Ahlert J., E. Shepard, N. Lomovskaya, E. Zazopoulos, A. Staffa, B.O. Bachmann, K. Huang, L. Fonstein, A. Czisny, R.E. Whitwam, C.M. Farnet, and J.S. Thorson. 2002. The calicheamicin gene cluster and its iterative type I enediyne PKS. Science 297, 1173-1176 DOI PUBMED ScienceOn |
2 | Grimm A., K. Madduri, A. Ali, and C.R. Hutchinson. 1994. Characterization of the Streptomyces peucetius ATCC 29050 genes encoding doxorubicin polyketide synthase. Gene 151, 1-10 DOI PUBMED ScienceOn |
3 | Russell D. W. and J. Sambrook. 2001. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, U.S.A |
4 | Jung Y.G., S.H. Kang, C.G. Hyun, Y.Y. Yang, C.M. Kang, and J. W. Suh. 2003. Isolation and characterization of bluensomycin biosynthetic genes from Streptomyces bluensis. FEMS Microbiol. Lett.219, 285-289 DOI ScienceOn |
5 | Stratmann A., T. Mahmud, S. Lee, J. Distler, H.G. Floss, and W. Piepersberg. 1999. The AcbC protein from Actinoplanes species is a C7-cyclitol synthase related to 3-dehydroquinate synthases and is involved in the biosynthesis of the alpha-glucosidase inhibitor acarbose. J. Biol. Chem. 274, 10889-10896 DOI ScienceOn |
6 | Brautaset T., O.N. Sekurova, H. Sletta, T.E. Ellingsen, A.R. Strlm, S. Valla, and S.B. Zotchev. 2000. Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway. Chem. Biol. 7. 395-403 DOI ScienceOn |
7 | Barna J.C.J. and D.H. Williams. 1984. The structure and mode of action of glycopeptide antibiotics of the vancomycin group. Ann. Rev. Microbiol. 38, 339-357 DOI ScienceOn |
8 | Huang J,C. J. Lih, K.H. Pan, and S.N. Cohen. 2001. Global analysis of growth phase responsive gene expression and regulation of antibiotic biosynthetic pathways in Streptomyces coelicolor using DNA microarrays. Genes Dev. 15, 3183-3192 DOI ScienceOn |
9 | Sekurova O., H. Sletta, T.E. Ellingsen, S. Valla, and S. Zotchev. 1999. Molecular cloning and analysis of a pleiotropic regulatory gene locus from the nystatin producer Streptomyces noursei ATCC11455. FEMS. Microbiol. Lett. 177, 297-304 DOI ScienceOn |
10 | Zotchev S., K. Haugan, O. Sekurova, H. Sletta, T.E. Ellingsen, and S. Valla. 2000. Identification of a gene cluster for antibacterial polyketide-derived antibiotic biosynthesis in the nystatin producer Streptomyces noursei ATCC 11455. Microbiology 146, 611-619 DOI PUBMED |
11 | Liu W., S. D. Christenson, S. Standage, and B. Shen. 2002. Biosynthesis of the enediyne antitumor antibiotic C-1027. Science 297, 1170-1173 DOI PUBMED ScienceOn |
12 | Mahmud T., S. Lee, and H.G. Floss. 2001. The biosynthesis of acarbose and validamycin. Chem. Rec. 1, 300-310 DOI ScienceOn |
13 | van Wageningen A.M., P.N. Kirkpatrick, D.H. Williams, B.R. Harris, J.K. Kershaw, N.J. Lennard, M. Jones, S.J. Jones, and P.J. Solenberg. 1998. Sequencing and analysis of genes involved in the biosynthesis of a vancomycin group antibiotic. Chem. Biol. 5, 155-162 DOI ScienceOn |
14 | Takano E, H. Kinoshita, V. Mersinias, G. Bucca, G. Hotchkiss, T. Nihira, C.P. Smith, M. Bibb, W. Wohlleben, and K. Chater. 2005. A bacterial hormone (the SCB1) directly controls the expression of a pathway-specific regulatory gene in the cryptic type I polyketide biosynthetic gene cluster of Streptomyces coelicolor.Mol. Microbiol. 56, 465-479 DOI ScienceOn |
15 | Weitnauer G., A. Muhlenweg, A. Trefzer, D. Hoffmeister, R.D. Sussmuth, G. Jung, K. Welzel, A. Vente, U. Girreser, and A. Bechthold. 2001. Biosynthesis of the orthosomycin antibiotic avilamycinA: deductions from the molecular analysis of the avi biosynthetic gene cluster of Streptomyces viridochromogenes Tu57 and production of new antibiotics. Chem. Biol. 8, 569-581 DOI ScienceOn |
16 | Hopwood, D.A., M.J. Bibb, K.F. Chater, T. Kieser, C.J. Bruton, H.M. Kieser, D.J. Lydiate, C.P. Smith, and J.M. Ward. 1985. Genetic manipulation of Streptomyces : a laboratory manual. The John Innes Foundation, Norwich, England |
17 | August P.R., L. Tang, Y.J. Yoon, S. Ning, R. Muller, T.W. Yu, M. Taylor, D. Hoffmann, C.G. Kim, X. Zhang, C.R. Hutchinson, and H.G. Floss. 1998. Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699. Chem. Biol. 5, 69-79 DOI ScienceOn |
18 | Steffensky M., A. Muhlenweg, Z.X. Wang, S.M. Li, and L. Heide. 2000. Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891. Antimicrob. Agents Chemother. 44, 1214-1222 DOI ScienceOn |
19 | Long B.H., W.C. Rose, D.M. Vyas, J.A. Matson, and S. Forenza. 2002. Discovery of antitumor indolocarbazoles: rebeccamycin, NSC 655649, and fluoroindolocarbazoles. Curr. Med. Chem. Anti-Canc. Agents. 2, 255-266 DOI ScienceOn |
20 | Schwecke T, J.F. Aparicio, I. Molnar, A. Konig, L.E. Khaw, S.F. Haydock, M. Oliynyk, P. Caffrey, J. Cortes, and J.B. Lester. 1995. The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin. Proc. Natl. Acad. Sci. USA. 92, 7839-7843 DOI ScienceOn |
21 | Distler J., A. Ebert, K. Mansouri, K. Pissowotzki, M. Stockmann, and W. Piepersberg. 1987. Gene cluster for streptomycin synthesis in Streptomyces griseus: nucleotide sequence of three genes and analysis of transcriptional activity. Nucleic Acids Res. 15, 8041-8056 DOI ScienceOn |
![]() |