Browse > Article
http://dx.doi.org/10.6117/kmeps.2020.27.4.107

Study on Improvement of Signal to Background Ratio of Laser-based Fluorescence Imaging System  

Kim, J.H. (Department of Cogno-Mechatronics Engineering, Pusan National University)
Jeong, M.Y. (Department of Cogno-Mechatronics Engineering, Pusan National University)
Publication Information
Journal of the Microelectronics and Packaging Society / v.27, no.4, 2020 , pp. 107-111 More about this Journal
Abstract
Recently, as an aging society progresses, a lot of interest in health and diagnosis is increasing, As the field of various bio-imaging systems for guided surgery capable of accurate diagnosis has emerged as important, a Fluorescence imaging system capable of accurate measurement and real-time confirmation has emerged as an important field. Fluorescence images currently being used are mainly in the NIR-I band, but many studies are in progress in the NIR-II band in order to improve resolution and confirm fluorescence deeply and accurately. In this paper, the difference between NIR-I and NIR-II, optical characteristics, and SBR (signal to background ration) of a fluorescent imaging system, was investigated using the finite element (FEM) method. After confirming, it was confirmed that the SBR was 16.2 times higher in the NIR-II area than in the NIR-I by making the skin phantom and measuring the fluorescence. It is confirmed that the enhancement in SBR of the Fluorescence imaging system is more effective in the NIR-II region than in the NIR-I region and expected to be used in application fields such as guided surgery, bio-sensor and also device which can detect the defect of optical devices.
Keywords
Fluorescence Imaging; NIR-IImaging; NIR-II Imaging; Mie scattering;
Citations & Related Records
Times Cited By KSCI : 4  (Citation Analysis)
연도 인용수 순위
1 F. Bray, J. Ferlay, I. Soerjomataram, R. L. Siegel, L. A. Torre, and A. Jemal, "Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries", CA: a cancer journal for clinicians, 68(6), 394 (2018).   DOI
2 D. Xu, F. Teng, Z. Wang, and N. Lu, "Droplet-confined electroless deposition of silver nanoparticles on ordered superhydrophobic structures for high uniform SERS measurements", ACS Applied Materials & Interfaces, 9(25), 21548 (2017).   DOI
3 Q. X. Yang, J. Wang, J. Wang, C. M. Collins, C. Wang, and M. B. Smith, "Reducing SAR and enhancing cerebral signal?to?noise ratio with high permittivity padding at 3 T", Magnetic resonance in medicine, 65(2), 358 (2011).   DOI
4 P. Beard, "Biomedical photoacoustic imaging", Interface focus, 1(4), 602 (2011).   DOI
5 D. A. Boas, A. M. Dale, and M. A. Franceschini, "Diffuse optical imaging of brain activation: approaches to optimizing image sensitivity, resolution, and accuracy", Neuroimage, 23, S275 (2004).   DOI
6 T. Kim, K. H. Seo, H. K. Lee, and M. Y. Jeong, "Development and Packaging of Multi-channel Imaging Module for Near-infrared Fluorescence Imaging System", J. Microelectron. Packag. Soc, 26(2), 59 (2019).   DOI
7 T. Kim, C. O'Brien, H. S. Choi, and M. Y. Jeong, "Fluorescence molecular imaging systems for intraoperative imageguided surgery", Applied Spectroscopy Reviews, 53(2-4), 349 (2018).   DOI
8 I. S. Saidi, S. L. Jacques, and F. K. Tittel, "Mie and Rayleigh modeling of visible-light scattering in neonatal skin", Applied optics, 34(31), 7410 (1995).   DOI
9 T. Kim, S. U. Cho, C. S. Park, H. G. Lee, D. I. Kim, and M. Y. Jeong, "A study on fluorescence imaging system characteristics depending on tilting of band pass filter", J. Microelectron. Packag. Soc, 23(2), 85 (2016).   DOI
10 L. Shi, L. A. Sordillo, A. Rodriguez?Contreras, and R. Alfano, "Transmission in near?infrared optical windows for deep brain imaging", Journal of biophotonics, 9(1-2), 38 (2016).   DOI
11 A. N. Bashkatov, E. A. Genina, V. I. Kochubey, M. M. Stolnitz, T. A. Bashkatova, O. V. Novikova, A. Y. Peshkova, and V. V. Tuchin, "Optical properties of melanin in the skin and skinlike phantoms", Proc. Controlling tissue optical properties: applications in clinical study, Amsterdam, Netherlands, 4162, 219, International Society for Optics and Photonics (2000).
12 J. A. Carr, D. Franke, J. R. Caram, C. F. Perkinson, M. Saif, V. Askoxylakis, M. Datta, D. Fukumura, R. K. Jain, M. G. Bawendi, and O. T. Bruns, "Shortwave infrared fluorescence imaging with the clinically approved near-infrared dye indocyanine green", Proc. National Academy of Sciences (PNAS), 115(17), 4465, PNAS (2018).   DOI