Browse > Article
http://dx.doi.org/10.4097/kjae.2009.57.3.277

The use of intra-cellular signaling pathways in anesthesiology and pain medicine field  

Joo, Jin-Deok (Department of Anesthesiology and Pain Medicine, College of Medicine, The Catholic University of Korea)
Publication Information
Korean Journal of Anesthesiology / v.57, no.3, 2009 , pp. 277-283 More about this Journal
Abstract
At the level of individual cells, signaling is crucial in cell division, differentiation, metabolic control and death. Reception of the signals depends on receptor proteins that are usually at the cell surface, and these receptor proteins bind the signal molecule. The binding activates the receptor, which in turn activates one or more of the intra-cellular signaling pathways. These relay chains of molecules, mainly intra-cellular signaling proteins, process the signal inside the receiving cell and distribute it to the appropriate intra-cellular targets. Cell signaling pathways are involved in the pathophysiology of many diseases and also in the mechanisms of action of many drugs, including local and general anesthetics. Knowledge of the basic cell signaling mechanisms is essential for understanding many of the pathophysiologic and pharmacologic mechanisms. Therefore, if we focus on applying the new cellular and molecular biologic research, these efforts could identify the mechanism of diseases and help develop new drugs in the field of anesthesiology and pain medicine.
Keywords
G protein-coupled receptor; Intra-cellular signaling pathway; PI3K/Akt signaling pathway; Western blots;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Alberts B. Molecular Biology of the Cell. 5th ed. New York, Garland Science. 2007, pp 879-964
2 Song XS, Cao JL, Xu YB, He JH, Zhang LC, Zeng YM. Activation of ERK/CREB pathway in spinal cord contributes to chronic constrictive injury-induced neuropathic pain in rats. Acta Pharmacol Sin 2005; 26: 789-98   DOI   ScienceOn
3 Kevin LG, Novalija E, Stowe DF. Reactive oxygen species as mediators of cardiac injury and protection: the relevance to anesthesia practice. Anesth Analg 2005; 101: 1275-87   DOI   ScienceOn
4 Tas PW, Stöossel C, Roewer N. Inhibition of the histamine-induced $Ca^{2+}$ influx in primary human endothelial cells (HUVEC) by volatile anaesthetics. Eur J Anaesthesiol 2008; 25: 976-85   DOI   ScienceOn
5 Lee HT, Kim M, Jan M, Emala CW. Anti-inflammatory and antinecrotic effects of the volatile anesthetic sevoflurane in kidney proximal tubule cells. Am J Physiol Renal Physiol 2006; 291:F67-78   DOI   ScienceOn
6 Hollmann MW, Wieczorek KS, Berger A, Durieux ME. Local anesthetic inhibition of G protein-coupled receptor signaling by interference with Galpha(q) protein function. Mol Pharmacol 2001; 59:294-301   DOI   PUBMED
7 Wickley PJ, Shiga T, Murray PA, Damron DS. Propofol decreases myofilament $Ca^{2+}$ sensitivity via a protein kinase C-, nitric oxide synthase-dependent pathway in diabetic cardiomyocytes. Anesthesiology 2006; 104: 978-87   DOI   ScienceOn
8 Xu JT, Xin WJ, Wei XH, Wu CY, Ge YX, Liu YL, et al. p38 activation in uninjured primary afferent neurons and in spinal microglia contributes to the development of neuropathic pain induced by selective motor fiber injury. Exp Neurol 2007; 204: 355-65   DOI   ScienceOn
9 Diez D, Grijota-Martinez C, Agretti P, De Marco G, Tonacchera M, Pinchera A, et al. Thyroid hormone action in the adult brain: gene expression profiling of the effects of single and multiple doses of triiodo-L-thyronine in the rat striatum. Endocrinology 2008; 149: 3989-4000   DOI   ScienceOn
10 Faden AI, Simon RP. A potential role for excitotoxins in the pathophysiology of spinal cord injury. Ann Neurol 1988; 23: 623-6   DOI   ScienceOn
11 Willis WD. Long-term potentiation in spinothalamic neurons. Brain Res Brain Res Rev 2002; 40: 202-14   DOI   PUBMED   ScienceOn
12 Chizh BA. Low dose ketamine: a therapeutic and research tool to explore N-methyl-D-aspartate (NMDA) receptor-mediated plasticity in pain pathways. J Psychopharmacol 2007; 21: 259-71   DOI   ScienceOn
13 Fukuda K, Shoda T, Mima H, Uga H. Midazolam induces expression of c-Fos and EGR-1 by a non-GABAergic mechanism. Anesth Analg 2002; 95: 373-8   DOI   ScienceOn
14 Gallos G, Jones DR, Nasr SH, Emala CW, Lee HT. Local anesthetics reduce mortality and protect against renal and hepatic dysfunction in murine septic peritonitis. Anesthesiology 2004; 101:902-11   DOI   ScienceOn
15 Joo JD, In JH, Jung HS, Kim YS, Kim DW, Choi JW, et al. Lidocaine attenuates the expression of ERK1/2 and CREB in a neuropathic pain model of rats. Korean J Anesthesiol 2009; 56:319-24   DOI   ScienceOn
16 Tegeder I, Geisslinger G. Opioids as modulators of cell death and survival--unraveling mechanisms and revealing new indications. Pharmacol Rev 2004; 56: 351-69   DOI   ScienceOn
17 Joo JD, Kim M, D'Agati VD, Lee HT. Ischemic preconditioning provides both acute and delayed protection against renal ischemia and reperfusion injury in mice. J Am Soc Nephrol 2006; 17:3115-23   DOI   ScienceOn
18 Wu GJ, Chen TL, Ueng YF, Chen RM. Ketamine inhibits tumor necrosis factor-alpha and interleukin-6 gene expressions in lipopolysaccharide-stimulated macrophages through suppression of toll-like receptor 4-mediated c-Jun N-terminal kinase phosphorylation and activator protein-1 activation. Toxicol Appl Pharmacol 2008; 228: 105-13   DOI   PUBMED   ScienceOn
19 Jawan B, Kao YH, Goto S, Pan MC, Lin YC, Hsu LW, et al. Propofol pretreatment attenuates LPS-induced granulocyte-macrophage colony-stimulating factor production in cultured hepatocytes by suppressing MAPK/ERK activity and NF-kappaB translocation. Toxicol Appl Pharmacol 2008; 229: 362-73   DOI   PUBMED   ScienceOn
20 Tan M, Groszer M, Tan AM, Pandya A, Liu X, Xie CW. Phosphoinositide 3-kinase cascade facilitates mu-opioid desensitization in sensory neurons by altering G-protein-effector interactions. J Neurosci 2003; 23: 10292-301
21 Steurer M, Schläapfer M, Steurer M, Z'graggen BR, Booy C, Reyes L, et al. The volatile anaesthetic sevoflurane attenuates lipopolysaccharide-induced injury in alveolar macrophages. Clin Exp Immunol 2009; 155: 224-30   DOI   ScienceOn
22 Lee HT, Kim M, Song JH, Chen SW, Gubitosa G, Emala CW. Sevoflurane-mediated TGF-beta1 signaling in renal proximal tubule cells. Am J Physiol Renal Physiol 2008; 294: F371-8   DOI   PUBMED
23 Ivanics T, Miklóos Z, Déezsi L, Ikréenyi K, Tóoth A, Roemen TH, et al. Concomitant accumulation of intracellular free calcium and arachidonic acid in the ischemic-reperfused rat heart. Mol Cell Biochem 2001; 226: 119-28   DOI   PUBMED   ScienceOn
24 Bouwman RA, Musters RJ, van Beek-Harmsen BJ, de Lange JJ, Lamberts RR, Loer SA, et al. Sevoflurane-induced cardioprotection depends on PKC-alpha activation via production of reactive oxygen species. Br J Anaesth 2007; 99: 639-45   DOI   ScienceOn