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http://dx.doi.org/10.5657/KFAS.2014.0751

Anti-inflammatory Activity of Ethanol Extract of Undaria pinnatifida Root in RAW 264.7 Cells  

Kang, Bo-Kyeong (Department of Food Science and Technology/Institute of Food Science, Pukyong National University)
Ahn, Na-Kyung (Department of Food Science and Technology/Institute of Food Science, Pukyong National University)
Choi, Yeon-Uk (Department of Food Science and Technology/Institute of Food Science, Pukyong National University)
Kim, Min-Ji (Institute of Fisheries Sciences, Pukyong National University)
Bark, Si-Woo (Department of Food Science and Technology/Institute of Food Science, Pukyong National University)
Pak, Won-Min (Department of Food Science and Technology/Institute of Food Science, Pukyong National University)
Kim, Bo-Ram (Department of Food Science and Technology/Institute of Food Science, Pukyong National University)
Kim, Koth-Bong-Woo-Ri (Institute of Fisheries Sciences, Pukyong National University)
Ahn, Dong-Hyun (Department of Food Science and Technology/Institute of Food Science, Pukyong National University)
Publication Information
Korean Journal of Fisheries and Aquatic Sciences / v.47, no.6, 2014 , pp. 751-756 More about this Journal
Abstract
The anti-inflammatory effects of the ethanol extract of Undaria pinnatifida root (UPREE) were investigated using the lipopolysaccharide (LPS)-induced inflammatory response in RAW 264.7 cells by measuring the production of nitric oxide (NO), interleukin (IL)-6, tumor necrosis factor (TNF)-${\alpha}$, and IL-$1{\beta}$, and cell proliferation. We found that NO levels were reduced by 34% at $100{\mu}g/mL$. Moreover, the production of IL-6 and TNF-${\alpha}$ was suppressed by the UPREE treatment. In particular, the IL-6 production was inhibited by more than 30% at $100{\mu}g/mL$ UPREE. The proliferation of RAW 264.7 cells was measured by MTT assay, and we found no cytotoxicity in those cells treated with UPREE compared to the control. Our results suggest that UPREE shows promise as a therapeutic anti-inflammatory treatment.
Keywords
Undaria pinnatifida; Anti-inflammatory Activity; IL-6; TNF-${\alpha}$;
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Times Cited By KSCI : 11  (Citation Analysis)
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