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http://dx.doi.org/10.5657/kfas.2010.43.6.623

Distribution of Fluoroquinolones in the Carp (Cyprinus carpio) and Eel (Anguilla japonica) following their Oral Administration  

Jo, Mi-Ra (Southwest Sea Fisheries Research Institute, NFRDI)
Park, Kun-Ba-Wui (Southwest Sea Fisheries Research Institute, NFRDI)
Lee, Hee-Jung (Southwest Sea Fisheries Research Institute, NFRDI)
Kim, Ji-Hoe (Southeast Sea Fisheries Research Institute, NFRDI)
Lee, Tae-Seek (West Sea Fisheries Research Institute, NFRDI)
Jung, Sung-Hee (Aquaculture Research Institute, NFRDI)
Lee, Doo-Seog (Food Safety Research Division, NFRDI)
Yoon, Ho-Dong (Food Safety Research Division, NFRDI)
Kim, Poong-Ho (Food Safety Research Division, NFRDI)
Publication Information
Korean Journal of Fisheries and Aquatic Sciences / v.43, no.6, 2010 , pp. 623-628 More about this Journal
Abstract
The distribution of fluoroquinolones was investigated in the carp (Cyprinus carpio) and eel (Anguilla japonica) after an oral dose of 20 mg/kg body weight/day for 35 days. Blood samples were collected at 5 and 10 hours and 1, 2, 3, 5, 7, 9, 13, 20, 30, and 35 days after treatment. The fluoroquinolone concentrations were determined high- performance liquid chromatography with an ultraviolet detector. The recovery rates of fluoroquinolones in the fish samples ranged from 91.4-96.6, 91.2-96.5, and 90.4-98.6% for concentrations of 0.1, 0.5, and $1.0\;{\mu}g/g$, respectively. In the blood of carp, ciprofloxacin, enrofloxacin, norfloxacin, and sarafloxacin reached maximums level of 11.03, 9.37, 9.10, and $9.81\;{\mu}g/g$ 10 hours, 1 day, 10 hours, and 10 hours after treatment, respectively. In the eel blood, these reached maximum levels of 12.65, 11.18, 11.91, and $8.74\;{\mu}g/g$ all at 10 hours. Carp sample concentrations of ciprofloxacin, enrofloxacin, norfloxacin, and sarafloxacin were not measurable 20, 30, 20, and 20 days after treatment, respectively, in all experiments (
Keywords
Fluoroquinolones; Oral administration; Carp; Eel; HPLC;
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