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http://dx.doi.org/10.5657/kfas.2005.38.4.219

Biological Activities of Low Molecular Weight Substances Fractionated from the Seasoned and Smoked Products of Skipjack Tuna (Euthynus pelamis)  

LEE Jung Min (Faculty of Marine Bioscience and Technology, Kangnung National University)
CHOI Geun Pyo (Department of Food and Life Science, Gangwon Provincial University)
WON Moo Ho (College of Medicine, Hallym University)
KIM Sang Moo (Faculty of Marine Bioscience and Technology, Kangnung National University)
Publication Information
Korean Journal of Fisheries and Aquatic Sciences / v.38, no.4, 2005 , pp. 219-225 More about this Journal
Abstract
We studied the anticancer, antioxidative, ACE inhibitory, antithrombic, and cerebral ischemia inhibitory activities, of low molecular weight substances fractionated from the seasoned and smoked products of skipjack tuna (Euthynus pelamis). Low molecular weight substances fractionated from the liquid extract of seasoned and smoked skipjack tuna powder showed 7 peaks on gel permeation chromatography. Anticancer activity was the highest at Peak 3 $(54.23%)$ followed by Peak 4 $(41.58\%)$. The potency order of antioxidative activity was the highest at Peak 3 $(94.14\%)$ followed by Peak 2 $(82.07\%)$ and Peak 5 $(81.24\%)$. ACE inhibitory activity was the highest at Peak 3 $(67.27\%)$ followed by Peak 5 $(45.62\%)$. But there was weak anti thrombotic effect (PT and APTT) in the low molecular weight substances of the seasoned and smoked products of skipjack tuna. Cerebral ischemia inhibitory activity was the highest at Peak 3 $(80.0\%)$ followed by Peak 5 $(40.0\%)$.
Keywords
Euthynus pelamis; Skipjack tuna; Biological activity; Low molecular weight substances;
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