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http://dx.doi.org/10.5657/kfas.2003.36.6.568

The Effects of Polymannuronate on Leptin in Serum and Liver of Rats  

KIM In Hye (Faculty of Food Science and Biotechnology, Pukyong National University)
LEE Dong Soo (Biotechnology Research Center, KBP Co. Ltd.)
KWON Ji Young (Faculty of Food Science and Biotechnology, Pukyong National University)
KWON Mi Jin (Faculty of Food Science and Biotechnology, Pukyong National University)
NAM Teak Jeong (Faculty of Food Science and Biotechnology, Pukyong National University)
Publication Information
Korean Journal of Fisheries and Aquatic Sciences / v.36, no.6, 2003 , pp. 568-572 More about this Journal
Abstract
This study investigated the effects of polymannuronate feeding on cholesterol levels and leptin in the serum and liver of Sprague-Dawely rats. After one week of basal diet feeding, four week old S.D. male rats were fed with polymannuronate. The feeding efficiency of the polymannuronate fed group averaged around 0.27, which was 0.02-0.03 lower than that of the control group, and liver weight, also had a lower increase. The liver tissue tagging of rats by staining fat drops increased in the cholesterol fed group. RIA and RT-PCR were used to determine the expression of leptin in the serum and liver of rats. The polymannuronate fed group had a larger reduction in the serum and liver leptin than the cholesterol fed group. The RT-PCR results showed that leptin mRNA was expressed in the liver. The polymannuronate fed group had a larger reduction in liver leptin mRNA expression than the cholesterol fed group. The above results suggest that feeding of polymannuronate improves the physiological function of rats by changing serum and liver lipid composition and the expression of leptin was repressed at a molecular level.
Keywords
polymannuronate; Leptin; Leptin mRNA; Rats;
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