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http://dx.doi.org/10.5734/JGM.2018.15.1.1

Clinical significance of sonographic soft markers: A review  

Kim, Mi Sun (Department of Obstetrics and Gynecology, CHA Bundang Medical Center, CHA University School of Medicine)
Kang, Sukho (Department of Obstetrics and Gynecology, CHA Bundang Medical Center, CHA University School of Medicine)
Cho, Hee Young (Department of Obstetrics and Gynecology, CHA Bundang Medical Center, CHA University School of Medicine)
Publication Information
Journal of Genetic Medicine / v.15, no.1, 2018 , pp. 1-7 More about this Journal
Abstract
Sonographic findings with little or no pathological significance, known as soft markers, are often found in aneuploidy fetuses. After normal screening for the aneuploidy in first trimester, there are no uniform recommendations regarding when to disregard or put on clinical significance in isolated soft markers. Associations between some soft markers and adverse pregnancy outcomes including intrauterine fetal death, preterm birth, fetal growth restriction, and congenital infection have been reported in euploidy fetuses. The present article aims to review recent literatures about the clinical significance of soft markers after normal first trimester combined screening or noninvasive prenatal testing, and propose a simple clinical summary for management of specific soft markers in pregnancies.
Keywords
Aneuploidy; Ultrasonography;
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