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http://dx.doi.org/10.5124/jkma.2018.61.11.670

Pathophysiology and new treatment of itch  

Jung, Min Je (Department of Dermatology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine)
Choi, Yong Won (Department of Dermatology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine)
Chung, Bo Young (Department of Dermatology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine)
Park, Chun Wook (Department of Dermatology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine)
Kim, Hye One (Department of Dermatology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine)
Publication Information
Journal of the Korean Medical Association / v.61, no.11, 2018 , pp. 670-677 More about this Journal
Abstract
Many of the patients visit the doctors because of itching sensation. Itching is an unpleasant sensation. In the epidermal keratinocytes, various neurotransmitters and receptors are related itching. The itch signal is mainly transmitted through the lateral spinal ganglion-derived nerve fibers extending to the lower epidermis. Many mediators such as histamine are involved in the itching pathway. It can be helpful in the treatment of patients having itching sensation with a lot of new therapies from the basic medication such as antihistamines. Also, many drugs are currently under study.
Keywords
Pruritus; Etiology; Therapy;
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