Browse > Article
http://dx.doi.org/10.4163/jnh.2019.52.5.465

Serum 25-hydroxyvitamin D and cognitive function in Korean older adults living in rural area  

Shin, Ye Som (Department of Clinical Nutrition, Graduate School of Public Health, Dongduk Women's University)
Choi, Bo Youl (Department of Preventive Medicine, College of Medicine, Hanyang University)
Kim, Mi Kyung (Department of Preventive Medicine, College of Medicine, Hanyang University)
Yang, Yoon Jung (Department of Food and Nutrition, School of Natural Science, Dongduk Women's University)
Publication Information
Journal of Nutrition and Health / v.52, no.5, 2019 , pp. 465-474 More about this Journal
Abstract
Purpose: This study examined the association between the serum 25-hydroxyvitamin D concentration and the cognitive functions in Korean elderly. Methods: The subjects were 393 adults aged 60 years or older who participated in the Yangpyeong cohort between July 2009 and August 2010. The subjects were classified into deficiency, insufficiency, or adequacy groups according to the serum 25-hydroxyvitamin D concentration diagnostic criteria suggested by the US Institute of Medicine (IOM). The cognitive function was assessed based on the Korean version of the Mini-Mental State Examination (MMSE-KC). The dietary intake was assessed using the quantitative food frequency questionnaire with 106 food items. Results: The proportions of deficiency, insufficiency, or adequacy in serum 25-hydroxyvitamin D were 6.6%, 44.5%, and 48.9%, respectively. The serum 25-hydroxyvitamin D concentration was significantly higher in men than in women and in outdoor workers than in other occupations. The adequacy group had higher MMSE-KC scores than the other two groups, but not to a significant degree. The proportion of cognitive impairment tended to decrease with increasing serum vitamin D concentration to deficiency, insufficiency, and adequacy (p for trend = 0.029). The deficiency group had a 2.28 times higher risk of cognitive impairment than the adequacy group, but the difference was not statistically significant (OR, 2.28; 95% CI, 0.18 ~ 1.07, p for trend = 0.119). Conclusion: The serum vitamin D concentration tended to be associated with the cognitive function in elderly Koreans living in rural areas. To confirm the associations, further longitudinal studies with large samples were required.
Keywords
serum vitamin D; cognitive function; mild cognitive impairment; elderly;
Citations & Related Records
Times Cited By KSCI : 4  (Citation Analysis)
연도 인용수 순위
1 Wilson VK, Houston DK, Kilpatrick L, Lovato J, Yaffe K, Cauley JA, et al. Relationship between 25-hydroxyvitamin D and cognitive function in older adults: the Health, Aging and Body Composition Study. J Am Geriatr Soc 2014; 62(4): 636-641.   DOI
2 Llewellyn DJ, Lang IA, Langa KM, Muniz-Terrera G, Phillips CL, Cherubini A, et al. Vitamin D and risk of cognitive decline in elderly persons. Arch Intern Med 2010; 170(13): 1135-1141.   DOI
3 Moon JH, Lim S, Han JW, Kim KM, Choi SH, Kim KW, et al. Serum 25-hydroxyvitamin D level and the risk of mild cognitive impairment and dementia: the Korean Longitudinal Study on Health and Aging (KLoSHA). Clin Endocrinol (Oxf) 2015; 83(1): 36-42.   DOI
4 Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium; Ross AC, Taylor CL, Yaktine AL, Del Valle HB. Dietary reference intakes for calcium and vitamin D. Washington, D.C.: National Academies Press; 2011.
5 Lee JH, Lee KU, Lee DY, Kim KW, Jhoo JH, Kim JH, et al. Development of the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet (CERAD-K): clinical and neuropsychological assessment batteries. J Gerontol B Psychol Sci Soc Sci 2002; 57(1): P47-P53.   DOI
6 Lee DY, Lee KU, Lee JH, Kim KW, Jhoo JH, Kim SY, et al. A normative study of the CERAD neuropsychological assessment battery in the Korean elderly. J Int Neuropsychol Soc 2004; 10(1): 72-81.   DOI
7 Ahn Y, Kwon E, Shim JE, Park MK, Joo Y, Kimm K, et al. Validation and reproducibility of food frequency questionnaire for Korean genome epidemiologic study. Eur J Clin Nutr 2007; 61(12): 1435-1441.   DOI
8 Mithal A, Wahl DA, Bonjour JP, Burckhardt P, Dawson-Hughes B, Eisman JA, et al. Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int 2009; 20(11): 1807-1820.   DOI
9 Kim BK, Jung HM, Kim YK, Kim SY, Kim JH. Serum 25-Hydroxy Vitamin D3 Analysis of Korean People. Korean J Nucl Med Tech 2010; 14(1): 133-137.
10 van Dam RM, Snijder MB, Dekker JM, Stehouwer CD, Bouter LM, Heine RJ, et al. Potentially modifiable determinants of vitamin D status in an older population in the Netherlands: the Hoorn Study. Am J Clin Nutr 2007; 85(3): 755-761.   DOI
11 Yu AR, Kim JH, Kwon OR, Oh SY, Kim JH, Yang YJ. Associations between serum 25-hydroxyvitamin D and consumption frequencies of vitamin D rich foods in Korean adults and older adults. Korean J Community Nutr 2014; 19(2): 122-132.   DOI
12 Tardelli VS, Lago MP, Silveira DX, Fidalgo TM. Vitamin D and alcohol: a review of the current literature. Psychiatry Res 2017; 248: 83-86.   DOI
13 Wacker M, Holick MF. Sunlight and Vitamin D: a global perspective for health. Dermatoendocrinol 2013; 5(1): 51-108.   DOI
14 Yoo K, Cho J, Ly S. Vitamin D intake and serum 25-hydroxyvitamin D levels in Korean adults: analysis of the 2009 Korea National Health and Nutrition Examination Survey (KNHANES IV-3) using a newly established vitamin D database. Nutrients 2016; 8(10): 610.   DOI
15 Kuhn T, Kaaks R, Teucher B, Hirche F, Dierkes J, Weikert C, et al. Dietary, lifestyle, and genetic determinants of vitamin D status: a cross-sectional analysis from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Germany study. Eur J Nutr 2014; 53(3): 731-741.   DOI
16 Thompson JM, Li T, Park MK, Qureshi AA, Cho E. Estimated serum vitamin D status, vitamin D intake, and risk of incident alopecia areata among US women. Arch Dermatol Res 2016; 308(9): 671-676.   DOI
17 Ministry of Health and Welfare, The Korean Nutrition Society. Dietary reference intakes for Koreans 2015. Seoul: The Korean Nutrition Society; 2016. p.23-24.
18 Eyles DW, Smith S, Kinobe R, Hewison M, McGrath JJ. Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J Chem Neuroanat 2005; 29(1): 21-30.   DOI
19 MacLaughlin J, Holick MF. Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest 1985; 76(4): 1536-1538.   DOI
20 Vaes AM, Brouwer-Brolsma EM, van der Zwaluw NL, van Wijngaarden JP, Berendsen AA, van Schoor N, et al. Food sources of vitamin D and their association with 25-hydroxyvitamin D status in Dutch older adults. J Steroid Biochem Mol Biol 2017; 173: 228-234.   DOI
21 Shin MY, Kwun IS, Vitamin D. Vitamin D: is it a vitamin or a hormone?. Food Ind Nutr 2012; 17(2): 1-6.
22 Buell JS, Scott TM, Dawson-Hughes B, Dallal GE, Rosenberg IH, Folstein MF, et al. Vitamin D is associated with cognitive function in elders receiving home health services. J Gerontol A Biol Sci Med Sci 2009; 64(8): 888-895.
23 Kalueff AV, Tuohimaa P. Neurosteroid hormone vitamin D and its utility in clinical nutrition. Curr Opin Clin Nutr Metab Care 2007; 10(1): 12-19.   DOI
24 Kennedy DO, Haskell CF. Vitamins and cognition: what is the evidence? Drugs 2011; 71(15): 1957-1971.   DOI
25 McCann JC, Ames BN. Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction? FASEB J 2008; 22(4): 982-1001.   DOI
26 Berwick M, Erdei EO. Vitamin D and melanoma incidence and mortality. Pigment Cell Melanoma Res 2013; 26(1): 9-15.   DOI
27 Lee DM, Tajar A, Ulubaev A, Pendleton N, O'Neill TW, O'Connor DB, et al. Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men. J Neurol Neurosurg Psychiatry 2009; 80(7): 722-729.   DOI
28 Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Arch Neurol 1999; 56(3): 303-308.   DOI
29 Moon Y, Han SH. Vitamin D deficiency and cognitive dysfunction. Dement Neurocogn Disord 2012; 11(4): 111-117.   DOI
30 Przybelski R, Agrawal S, Krueger D, Engelke JA, Walbrun F, Binkley N. Rapid correction of low vitamin D status in nursing home residents. Osteoporos Int 2008; 19(11): 1621-1628.   DOI
31 Burgener SC, Buettner L, Coen Buckwalter K, Beattie E, Bossen AL, Fick DM, et al. Evidence supporting nutritional interventions for persons in early stage Alzheimer's disease (AD). J Nutr Health Aging 2008; 12(1): 18-21.   DOI
32 Statistics Korea. Statistics on the elderly 2016 [Internet]. Daejeon: Statistics Korea; 2016 [cited 2016 Sep 23]. Available from: http://kostat.go.kr/portal/korea/kor_nw/1/6/1/index.board?bmode=read&aSeq=356426.
33 Ministry of Health and Welfare. Nationwide study on the prevalence of dementia in Korea elders [Internet]. Seoul: Ministry for Health and Welfare; 2012 [cited 2013 May 2]. Available from: http://www.mohw.go.kr/front_new/al/sal0301vw.jsp?PAR_MENU_ID=04&MENU_ID=0403&CONT_SEQ=286138&page=1.
34 Jung K, Lee YA, Kim SY, Chang N. Associations of cognitive function and dietary factors in elderly patients with Alzheimer's disease. Korean J Nutr 2008; 41(8): 718-732.
35 Choi KG. Neuropathology of MCI: view from relationships with aging and Alzheimer's disease. Dement Neurocogn Disord 2003; 2(2): 101-107.
36 Bae JB, Kim YJ, Han JW, Kim TH, Park JH, Lee SB, et al. Incidence of and risk factors for Alzheimer's disease and mild cognitive impairment in Korean elderly. Dement Geriatr Cogn Disord 2015; 39(1-2): 105-115.   DOI
37 Wengreen HJ, Neilson C, Munger R, Corcoran C. Diet quality is associated with better cognitive test performance among aging men and women. J Nutr 2009; 139(10): 1944-1949.   DOI
38 Kim S, Choi BY, Nam JH, Kim MK, Oh DH, Yang YJ. Cognitive impairment is associated with elevated serum homocysteine levels among older adults. Eur J Nutr 2019; 58(1): 399-408.   DOI
39 Scarmeas N, Stern Y, Mayeux R, Manly JJ, Schupf N, Luchsinger JA. Mediterranean diet and mild cognitive impairment. Arch Neurol 2009; 66(2): 216-225.   DOI
40 Kim J, Yu A, Choi BY, Nam JH, Kim MK, Oh DH, et al. Dietary patterns and cognitive function in Korean older adults. Eur J Nutr 2015; 54(2): 309-318.   DOI
41 Chei CL, Raman P, Yin ZX, Shi XM, Zeng Y, Matchar DB. Vitamin D levels and cognition in elderly adults in China. J Am Geriatr Soc 2014; 62(11): 2125-2129.   DOI
42 Devore EE, Grodstein F, van Rooij FJ, Hofman A, Stampfer MJ, Witteman JC, et al. Dietary antioxidants and long-term risk of dementia. Arch Neurol 2010; 67(7): 819-825.   DOI
43 Llewellyn DJ, Lang IA, Langa KM, Melzer D. Vitamin D and cognitive impairment in the elderly U.S. population. J Gerontol A Biol Sci Med Sci 2011; 66(1): 59-65.   DOI
44 Selhub J, Miller JW. The pathogenesis of homocysteinemia: interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine. Am J Clin Nutr 1992; 55(1): 131-138.   DOI
45 van Schoor NM, Lips P. Worldwide vitamin D status. Best Pract Res Clin Endocrinol Metab 2011; 25(4): 671-680.   DOI
46 Jung IK. Prevalence of vitamin D deficiency in Korea: results from KNHANES 2010 to 2011. J Nutr Health 2013; 46(6): 540-551.   DOI
47 Lim S, Shin H, Kim MJ, Ahn HY, Kang SM, Yoon JW, et al. Vitamin D inadequacy is associated with significant coronary artery stenosis in a community-based elderly cohort: the Korean Longitudinal Study on Health and Aging. J Clin Endocrinol Metab 2012; 97(1): 169-178.   DOI
48 Lips P. Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev 2001; 22(4): 477-501.   DOI
49 Kim SH, Park YM, Choi BY, Kim MK, Roh S, Kim K, et al. Associations of serum levels of vitamins A, C, and E with the risk of cognitive impairment among elderly Koreans. Nutr Res Pract 2018; 12(2): 160-165.   DOI