Browse > Article
http://dx.doi.org/10.4163/jnh.2017.50.6.543

Effects of fermented blueberry liquid in high-fat diet-induced obese C57BL/6J mice  

Jeon, Jong-Hee (Department of Lifestyle-Medicine, Chonbuk National University)
Kim, Bohkyung (Department of Food Science and Human Nutrition, Chonbuk National University)
Mun, Eun-Gyung (Department of Food Science and Human Nutrition, Chonbuk National University)
Cha, Youn-Soo (Department of Food Science and Human Nutrition, Chonbuk National University)
Yu, Ok-Kyeong (Department of Obesity Research Center, Chonbuk National University)
Publication Information
Journal of Nutrition and Health / v.50, no.6, 2017 , pp. 543-551 More about this Journal
Abstract
Purpose: The objective of the present study was to determine whether fermentation can increase the protective effects of blueberry liquid in a high-fat diet-induced obese mice model. Methods: Male C57BL/6J mice were fed a high-fat diet (HD, 60% fat, w/w,), HD supplemented with 10 ml/kg BW/day of blueberry liquid (BHD, blueberry high-fat diet), or HD supplemented with 10 ml/kg BW/day of fermented blueberry liquid (FBHD, fermented blueberry high-fat diet) for 10 weeks. Results: There were significant decreases in the body, epididymal adipose tissue, and liver weights of blueberry-fed groups compared to HD, whereas there were no significant differences in food intake among the groups. Furthermore, blueberry liquid groups, especially fermented blueberry liquid, significantly attenuated the contents of hepatic triglycerides and total cholesterol induced by HD. Serum LDL-cholesterol was significantly lower in the BHD and FBHD-fed groups, whereas FBHD significantly increased the serum HDL-cholesterol level compared to the control. Concentrations of aspartate transaminase, alanine transaminase, and leptins in serum were also reduced by blueberry liquid supplementation. The mRNA expression of hepatic acetyl CoA carboxylase was significantly reduced in both the BHD and FBHD groups compared to HD. Furthermore, FBHD altered the mRNA expression level of hepatic lipolysis genes. Conclusion: In conclusion, these results suggest that blueberry, especially fermented blueberry liquid, may improve obesity-related abnormalities.
Keywords
high-fat diet; fermented blueberry liquid; anti-obesity; C57BL/6J;
Citations & Related Records
Times Cited By KSCI : 12  (Citation Analysis)
연도 인용수 순위
1 Choi SH. Quality characteristics of Korean wheat bread prepared with substitutions of naturally fermented blueberry starters. J East Asian Soc Diet Life 2013; 23(5): 546-560.
2 Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972; 18(6): 499-502.
3 Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 1957; 226(1): 497-509.
4 Koppen A, Kalkhoven E. Brown vs white adipocytes: the PPAR ${\gamma}$ coregulator story. FEBS Lett 2010; 584(15): 3250-3259.   DOI
5 Ferre P. The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity. Diabetes 2004; 53 Suppl 1: S43-S50.   DOI
6 Shin JH, Han SM, Kim AJ. The effects of mulberry extract consumption on the serum levels of oxidant and inflammatory factors in middle-aged women with rheumatoid factors. J Korea Acad Ind Coop Soc 2012; 13(8): 3561-3569.   DOI
7 Rodriguez-Mateos A, Rendeiro C, Bergillos-Meca T, Tabatabaee S, George TW, Heiss C, Spencer JP. Intake and time dependence of blueberry flavonoid-induced improvements in vascular function: a randomized, controlled, double-blind, crossover intervention study with mechanistic insights into biological activity. Am J Clin Nutr 2013; 98(5): 1179-1191.   DOI
8 Mykkanen OT, Huotari A, Herzig KH, Dunlop TW, Mykkanen H, Kirjavainen PV. Wild blueberries (Vaccinium myrtillus) alleviate inflammation and hypertension associated with developing obesity in mice fed with a high-fat diet. PLoS One 2014; 9(12): e114790.   DOI
9 Tsuda T, Horio F, Uchida K, Aoki H, Osawa T. Dietary cyanidin 3-O-${\beta}$-D-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice. J Nutr 2003; 133(7): 2125-2130.   DOI
10 Vendrame S, Daugherty A, Kristo AS, Klimis-Zacas D. Wild blueberry (Vaccinium angustifolium)-enriched diet improves dyslipidaemia and modulates the expression of genes related to lipid metabolism in obese Zucker rats. Br J Nutr 2014; 111(2): 194-200.   DOI
11 Zheng W, Wang SY. Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries. J Agric Food Chem 2003; 51(2): 502-509.   DOI
12 Prior RL, Wu X, Gu L, Hager TJ, Hager A, Howard LR. Whole berries versus berry anthocyanins: interactions with dietary fat levels in the C57BL/6J mouse model of obesity. J Agric Food Chem 2008; 56(3): 647-653.   DOI
13 Koca I, Karadeniz B. Antioxidant properties of blackberry and blueberry fruits grown in the Black Sea Region of Turkey. Sci Hortic (Amsterdam) 2009; 121(4): 447-450.   DOI
14 Coban J, Evran B, Ozkan F, Cevik A, Dogru-Abbasoglu S, Uysal M. Effect of blueberry feeding on lipids and oxidative stress in the serum, liver and aorta of guinea pigs fed on a high-cholesterol diet. Biosci Biotechnol Biochem 2013; 77(2): 389-391.   DOI
15 Tall AR. Plasma high density lipoproteins. Metabolism and relationship to atherogenesis. J Clin Invest 1990; 86(2): 379-384.   DOI
16 Wu T, Tang Q, Gao Z, Yu Z, Song H, Zheng X, Chen W. Blueberry and mulberry juice prevent obesity development in C57BL/6 mice. PLoS One 2013; 8(10): e77585.   DOI
17 Park SJ, Jeon YJ, Kim HJ, Han JS. Anti-obesity effects of Ishige okamurae extract in C57BL/6J mice fed high-fat diet. Korean J Food Sci Technol 2013; 45(2): 199-205.   DOI
18 Gotto AM Jr, Farmer JA. Drug insight: the role of statins in combination with ezetimibe to lower LDL cholesterol. Nat Clin Pract Cardiovasc Med 2006; 3(12): 664-672.   DOI
19 Kalt W, Foote K, Fillmore SA, Lyon M, Van Lunen TA, McRae KB. Effect of blueberry feeding on plasma lipids in pigs. Br J Nutr 2008; 100(1): 70-78.   DOI
20 Johnson MH, Wallig M, Luna Vital DA, de Mejia EG. Alcohol-free fermented blueberry-blackberry beverage phenolic extract attenuates diet-induced obesity and blood glucose in C57BL/6J mice. J Nutr Biochem 2016; 31(31): 45-59.   DOI
21 Kim NY, Lee YD, Cho SC, Shin YC, Lee HY. Enhancement of anti-inflammation effect by fermentation process in Aronia melanocarpa (Michx.) Elliott extract. Korean J Med Crop Sci 2014; 22(6): 475-482.   DOI
22 Park JO, Jang HW. Effects of Sasa coreana Nakai on the lipid compositions of serum in high cholesterol diet rats. J Life Sci 2009; 19(8): 1145-1151.   DOI
23 Reed J. Cranberry flavonoids, atherosclerosis and cardiovascular health. Crit Rev Food Sci Nutr 2002; 42(3 Suppl): 301-316.   DOI
24 Wang Y, Cheng M, Zhang B, Nie F, Jiang H. Dietary supplementation of blueberry juice enhances hepatic expression of metallothionein and attenuates liver fibrosis in rats. PLoS One 2013; 8(3): e58659.   DOI
25 Castellani WJ. Metabolic and nutritional aspects of the atherogenic atypical lipoproteins: lipoprotein (a), remnant lipoproteins, and oxidized low-density lipoprotein. Nutr Res 2004; 24(9): 681-693.   DOI
26 Yu EJ, Lim HS. Effect of egg yolk supplementation to Korean-diet on human serum cholesterol. Korean J Nutr 1988; 21(4): 260-267.
27 Jang JY, Lee MK, Kim MJ, Cho SY. Effect of fiber on serum lipid metabolism in rats with diet-induced cholesterolemia. J Korean Soc Food Sci Nutr 1998; 27(6): 1211-1216.
28 Kim EJ, Kim YE, Kim GY. The anti-obesity effects of treadmill exercise and Gastrodia elata on the obesity rats induced high-fat diet. J Exerc Nutr Biochem 2007; 11(2): 61-68.
29 Weyer C, Funahashi T, Tanaka S, Hotta K, Matsuzawa Y, Pratley RE, Tataranni PA. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 2001; 86(5): 1930-1935.   DOI
30 Cnop M, Havel PJ, Utzschneider KM, Carr DB, Sinha MK, Boyko EJ, Retzlaff BM, Knopp RH, Brunzell JD, Kahn SE. Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex. Diabetologia 2003; 46(4): 459-469.   DOI
31 Gervois P, Torra IP, Fruchart JC, Staels B. Regulation of lipid and lipoprotein metabolism by PPAR activators. Clin Chem Lab Med 2000; 38(1): 3-11.   DOI
32 Im DY, Lee KI. Melanin production inhibitory activity of the dendropanax morbifera leaf extract fermented by Lactobacillus plantarum. Korean J Pharmacogn 2016; 47(1): 18-23.
33 Bae CR, Kwon DY, Cha YS. Anti-obesity effects of salted and unsalted Doenjang supplementation in C57BL/6J mice fed with high fat diet. J Korean Soc Food Sci Nutr 2013; 42(7): 1036-1042.   DOI
34 Yang Y, Morin PJ, Han WF, Chen T, Bornman DM, Gabrielson EW, Pizer ES. Regulation of fatty acid synthase expression in breast cancer by sterol regulatory element binding protein-1c. Exp Cell Res 2003; 282(2): 132-137.   DOI
35 Park MJ. Recent advances in regulating energy homeostasis and obesity. Korean J Pediatr 2005; 48(2): 126-137.
36 Benn T, Kim B, Park YK, Wegner CJ, Harness E, Nam TG, Kim DO, Lee JS, Lee JY. Polyphenol-rich blackcurrant extract prevents inflammation in diet-induced obese mice. J Nutr Biochem 2014; 25(10): 1019-1025.   DOI
37 Lefebvre P, Chinetti G, Fruchart JC, Staels B. Sorting out the roles of $PPAR{\alpha}$ in energy metabolism and vascular homeostasis. J Clin Invest 2006; 116(3): 571-580.   DOI
38 Moriarty JP, Branda ME, Olsen KD, Shah ND, Borah BJ, Wagie AE, Egginton JS, Naessens JM. The effects of incremental costs of smoking and obesity on health care costs among adults: a 7-year longitudinal study. J Occup Environ Med 2012; 54(3): 286-291.   DOI
39 Murakami K, Tobe K, Ide T, Mochizuki T, Ohashi M, Akanuma Y, Yazaki Y, Kadowaki T. A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and PPAR-gamma: effect of PPAR-alpha activation on abnormal lipid metabolism in liver of Zucker fatty rats. Diabetes 1998; 47(12): 1841-1847.   DOI
40 Hong SH. Obesity and subjective well-being. Korean J Health Econ Policy 2015; 21(1):31-49.
41 Kim RU. Identification and characterization of soy yogurtforming lactic acid bacteria [dissertation]. Busan: Pusan National University; 2010.
42 Chun JM, Bae JH. Preparation of fermented citrus peels extracts for their antimicrobial activity against Campylobacter jejuni. Korean J Food Cult 2015; 30(4): 475-480.   DOI
43 Bae MJ, Kim SJ, Ye EJ, Nam HS, Park EM. Study on the chemical composition of lotus root and functional evaluation of fermented lotus root drink. Korean J Food Cult 2008; 23(2): 222-227.
44 Jeong CH, Choi SG, Heo HJ. Analysis of nutritional compositions and antioxidative activities of Korean commercial blueberry and raspberry. J Korean Soc Food Sci Nutr 2008; 37(11): 1375-1381.   DOI
45 Su MS, Chien PJ. Antioxidant activity, anthocyanins, and phenolics of rabbiteye blueberry (Vaccinium ashei) fluid products as affected by fermentation. Food Chem 2007; 104(1): 182-187.   DOI
46 Yoon HH, Chae KS, Son RH, Jung JH. Antioxidant activity and fermentation characteristics of blueberry wine using traditional yeast. J Korean Soc Food Sci Nutr 2015; 44(6): 840-846.   DOI
47 Zmuda-Trzebiatowska E, Oknianska A, Manganiello V, Degerman E. Role of PDE3B in insulin-induced glucose uptake, GLUT-4 translocation and lipogenesis in primary rat adipocytes. Cell Signal 2006; 18(3): 382-390.   DOI
48 Harness E. The effect of polyphenol-rich black currant extract on lipogenic and inflammatory gene expression in diet induced obesity mice [dissertation]. Storrs (CT): University of Connecticut; 2015.
49 Lee DH, Hong JH. Physicochemical properties and storage stability of blueberry fermented by lactic acid bacteria. Korean J Food Preserv 2015; 22(6): 796-803.   DOI