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http://dx.doi.org/10.4163/jnh.2015.48.2.133

Effects of a Pueraria lobata-root based combination supplement containing Rehmannia glutinosa and aerobic exercise on improvement of metabolic dysfunctions in ovariectomized rats  

Oh, Sang A (Department of Nutritional Science and Food Management, Ewha Womans University)
Ok, Hyang Mok (Department of Nutritional Science and Food Management, Ewha Womans University)
Kim, Hye Jin (Department of Exercise Science, College of Health Sciences, Ewha Womans University)
Lee, Won Jun (Department of Exercise Science, College of Health Sciences, Ewha Womans University)
Kwon, Oran (Department of Nutritional Science and Food Management, Ewha Womans University)
Publication Information
Journal of Nutrition and Health / v.48, no.2, 2015 , pp. 133-139 More about this Journal
Abstract
Purpose: There is a fair amount of evidence indicating that increased risk of obesity and insulin resistance is associated with postmenopausal state, but can be modulated by diet and exercise. In this study, we explored whether a Pueraria lobata root-based supplement containing Rehmannia glutinosa (PR) and/or aerobic treadmill exercise can modify the metabolic changes associated with estrogen deficiency. Methods: Seventy rats were randomly assigned to the following groups for 8 weeks (n=10 per group): SHAM, sham-operated; PR0, ovariectomized (OVX) control; PR200, OVX with PR200 mg/kg B.W; PR400, OVX with PR400 mg/kg B.W; EPR0, OVX with exercise; EPR200, OVX with exercise and PR200 mg/kg B.W; EPR400, OVX with exercise and PR400 mg/kg B.W. Results: OVX induced significant increases in body weight, food intake, fat mass, LDL-cholesterol, and fasting blood glucose, confirming induction of menopausal symptoms. PR supplementation or exercise significantly suppressed the above mentioned changes through different regulatory elements in adipose tissue: PR supplement upregulated adiponectin gene expression and aerobic exercise upregulated adiponectin and insulin receptor gene expression and a combination of PR supplement and aerobic exercise showed an additive effect on adiponectin gene expression. Conclusion: Taken together, the results of this study suggest that PR supplement has a potential to provide health benefits in OVX rats through leptin and adiponectin secretion. In addition, the data suggest that combination of exercise and PR would have additive effects on metabolic dysfunction associated with estrogen deficiency.
Keywords
Pueraria lobata; Rehmannia glutinosa; aerobic exercise; metabolic dysfunction; ovariectomized rats;
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Times Cited By KSCI : 5  (Citation Analysis)
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