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http://dx.doi.org/10.4163/kjn.2010.43.4.342

Effects of Soy Protein, its Hydrolysate and Peptide Fraction on Lipid Metabolism and Appetite-Related Hormones in Rats  

Park, Ji-Hye (Department of Food and Nutrition & Research Institute of Human Ecology, Seoul National University)
Park, Mi-Na (Department of Food and Nutrition & Research Institute of Human Ecology, Seoul National University)
Lee, Im-Sik (R & D Center, Maeil Dairies Co. Ltd.)
Kim, Yong-Ki (R & D Center, Maeil Dairies Co. Ltd.)
Kim, Wan-Sik (R & D Center, Maeil Dairies Co. Ltd.)
Lee, Yeon-Sook (Department of Food and Nutrition & Research Institute of Human Ecology, Seoul National University)
Publication Information
Journal of Nutrition and Health / v.43, no.4, 2010 , pp. 342-350 More about this Journal
Abstract
This study was aimed to investigate whether soy protein hydrolysates had beneficial effects on serum and tissue lipid contents and appetite-related hormones as compared with intact soy protein. Four-week-old male Sprague-Dawley rats were fed AIN-93M diet containing high fat (18% w/w) with low protein (10% w/w). After four weeks, the rats were divided into four groups (n = 8/group) and fed experimental diets with different nitrogen sources and levels, respectively; 10% soy protein isolate (10SPI), 25% soy protein isolate (25SPI), 25% soy protein hydrolysates (25SPH) and 25% soy macro-peptide fractions (25SPP, MW $\geq$ 10,000) for six weeks. Weight gain was significantly higher in 25% nitrogen sources-fed groups than in 10% group (10SPI). In 25SPP, perirenal fat mass and serum total lipid were significantly lower than in other groups. As for appetite-related hormones, serum ghrelin concentration was not shown to be different among groups but leptin concentration was significantly decreased in 25SPP. It can be concluded that soy macro-peptide fractions as compared with intact soy protein may have beneficial effects on reducing fat mass and serum lipid.
Keywords
soy protein; hydrolysate; macro-peptide fraction; lipid; appetite;
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