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The Effect of Alpha-tocopherol Supplementation on the Improvement of Antioxidant Status and Lymphocyte DNA Damage in Postmenopausal Women  

Kim, Chang-Suk (Department of Food & Nutrition, Daedeok Valley Campus, Hannam University)
Kang, Hae-Jin (Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University)
Lee, Soon-Hee (Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University)
Park, Yoo-Kyoung (Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University)
Kang, Myung-Hee (Department of Food & Nutrition, Daedeok Valley Campus, Hannam University)
Publication Information
Journal of Nutrition and Health / v.40, no.8, 2007 , pp. 708-718 More about this Journal
Abstract
The purpose of this project was to evaluate whether vitamin E supplementation could improve the antioxidant status and lymphocyte DNA damage in Korean postmenopausal women. This was double blinded, placebo-controlled trial. Thirty-five subject were randomized to receive either placebo 400 mg/capsule or natural $\alpha$-tocopherol 400 IU/capsule, 2 times a day for 6 weeks. We measured plasma vitamin C, $\alpha$-tocopherol, $\gamma$-tocopherol, $\alpha$-carotenoid, $\beta$-carotenoid, lycopene concentration and tail length, %DNA in tail, tail moment in lymphocyte DNA damage index. Vitamin E supplementation group had significantly increased plasma vitamin C(p<0.05), $\alpha$-tocopherol(p<0.000), whereas $\gamma$-tocopherol(p<0.000) and tail length(p<0.05) were significantly decreased. However, placebo supplementation group also had significantly increased plasma vitamin C(p<0.05). In conclusion, our study shows that vitamin E supplementation to Korean postmenopausal women may partially improve antioxidant status and lymphocyte DNA damage.
Keywords
vitamin E supplementation; antioxidant status; lymphocyte DNA damage; postmenopausal;
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Times Cited By KSCI : 7  (Citation Analysis)
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