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The Effects of Ca and Mg Supplementation on Serum and Liver Lipid Parameters in Ovariectomized and Ca Deficiency Rats  

Bae, Yun-Jung (Department of Food and Nutrition, Sookmyung Women's University)
Kim, Mi-Hyun (Department of Food and Nutrition, Kangwon National University)
Sung, Chung-Ja (Department of Food and Nutrition, Sookmyung Women's University)
Publication Information
Journal of Nutrition and Health / v.40, no.7, 2007 , pp. 616-623 More about this Journal
Abstract
This study was carried out to investigate the Ca and Mg supplementation on the serum and liver lipid parameters in ovariectomized and Ca deficiency rats. Total 50 Sprague Dawley female rats (6 weeks) were divided into 5 groups and bred for 12 weeks: sham operated control group (SNCa), OVX Ca deficiency poop (OLCa) with Ca deficiency diet (0.1% Ca modified AIN-93N diet), OVX Ca deficiency & Mg supplement group (OLCaMg), OVX adequate Ca group (OACa; 0.5% Ca AIN-93N diet) and OVX adequate Ca & Mg supplement group (OACaMg). There were no significant difference among the five groups in serum total cholesterol, triglyceride and HDL-cholesterol levels. LDL-cholesterol of OVX groups was significantly higher than that of SNCa group (p < 0.01). AI (Atherogenic index), TPH (Total cholesterol/HDL-C) and LPH (LDL-C/HDL-C) of OACa group were significantly lower than those of OLCa groups. OACaMg group had significantly lower levels LDL, AI and TPH than OLCa group. There was no significant difference in lever cholesterol level. However, liver total fat content of OACa was significantly lower than that of OLCa. From the above the results, it is concluded that the accumulation level of calcium shows how the supplement of magnesium affects hyperlipidemia. Therefore, in order to prevent women#s hyperlipidemia after menopause, and to keep healthy, it is encourage able to consider how the supplement of magnesium relates calcium intake.
Keywords
Ca; Mg; ovariectomzied rats; hypolipidemic action;
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