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Effects of Maternal Folic Acid Nutritional Status on the Expression of Myelin Basic Protein in the Offspring  

Chae, Eun-Hye (Department of Nutritional Sciences, Ewha Womans University)
Kim, Soo-Jung (Department of Nutritional Sciences, Ewha Womans University)
Lee, Hwa-Young (Department of Anatomy, Ewha Womans Medical Center)
Chang, Nam-Soo (Department of Nutritional Sciences, Ewha Womans University)
Publication Information
Journal of Nutrition and Health / v.40, no.2, 2007 , pp. 130-137 More about this Journal
Abstract
Myelin basic protein (MBP), a major structural protein of the myelin, is thought to be important for the maintenance of myelin in the central nervous system (CNS). We investigated the effect of maternal folic acid nutritional status on the folate level and the synthesis of MBP in the offspring. In order to test this hypothesis, female Sprague-Dawley rats were fed either folic acid sufficient (8 mg/kg diet) or deficient (0 mg/kg diet) diet from 2 wks prior to the mating throughout the entire pregnancy, lactation and weaning period. We examined plasma folate level by the radioimmunoassay and homocysteine level by HPLC, respectively. The MBP expression was measured by the western blot analysis. The maternal folic acid deficiency decreased plasma folate level with a concomitant increase in plasma homocysteine level in their offspring. The maternal folic acid deficiency decreased hepatic levels of SAM and SAM/SAH ratio with a concomitant increase in hepatic levels of SAH and the MBP expression of spinal cord in their offspring at 7 wks of age. These results suggest that maternal folic acid nutritional status affect plasma folate and homocysteine level in their offspring. Moreover, the maternal folic acid deficiency mi호t inhibit the MBP expression of the spinal cord and disrupt many other vital CNS reactions in their offspring.
Keywords
myelin basic protein (MBP); folate; SAM/SAH ratio; spinal cord;
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1 Burgoon JM, Selhub J, Nadeau M, Sadler TW. Investigation of the effects of folate deficiency on embryonic development through the establishment of a folate deficient mouse model. Teratology 65(5): 219-227, 2002   DOI   ScienceOn
2 Scott JM, Weir DG, Molloy A, McPartlin J, Daly L, Kirke P. Folic acid metabolism and mechanisms of neural tube defects. Ciba Found Symp 181: 180-191, 1994
3 Surtees R. Demyelination and inborn errors of the single carbon transfer pathway. Eur J Pediatr 157: 118-121, 1998   DOI   ScienceOn
4 Araki A, Sako Y. Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection. J Chromatogr 422: 43-53, 1987   DOI
5 MRC Vitamin Study Research Group. Prevention of neural tube defects: result of Medical Research Council Vitamin Study. Lancet 338: 131-137, 1991   DOI
6 Liu MC, Akle V, Zheng W, Kitlen J, O'Steen B, Larner SF, Dave JR, Tortella FC, Hayes RL, Wang KKW. Extensive degradation of myelin basic protein isoforms by calpain following traumatic brain injury. J Neurochem 98: 700-712, 2006   DOI   ScienceOn
7 Ulfig N, Nickel J, Saretzki U. Alterations in myelin formation in fetal brains of twins. Pediatr Neurol 19: 287-293, 1998   DOI   ScienceOn
8 Ramaekers VT, Blau N. Cerebral folate deficiency. Dev Med Child Neurol 46: 843-851, 2004   DOI   ScienceOn
9 Faurschou M, Nielsen OJ, Jensen MK, Hasselbalch HC. High prevalence of hyperhomocysteinemia due to marginal deficiency of cobalamin or folate in chronic myeloproliferative disorders. Am J Hematol 65: 136-140, 2000   DOI   ScienceOn
10 Gospe SM, Gietzen DW, Summers PJ, Lunetta JM, Miller JW, Selhub J, Ellis WG, Clifford AJ. Behavioral and neurochemical changes in folate-deficient mice. Physiol Behav 58(5): 935-941, 1995   DOI   ScienceOn
11 Tanaka F, Kachi T, Yamada T, Sobue G. Auditory and visual event-related potentials and flash visual evoked potentials in Alzheimer's disease: correlations with Mini-Mental State Examination and Raven's Coloured Progressive Matrices. J Neurol Sci 156: 83-88, 1998   DOI   ScienceOn
12 Surtees R, Leonard J. Association of demyelination with deficiency of cerebrospinal-fluid S-adenosylmethionine in inborn errors of methyl-transfer pathway. Lancet 338(8782/8783): 1550-1554, 1991   DOI
13 Akiyama K, Ichinose S, Omori A, Sakurai Y, Asou H. Study of expression of myelin basic proteins (MBPs) in developing rat brain using a novel antibody reacting with four major isoforms of MBP. J Neurosci Res 68: 19-28, 2002   DOI   ScienceOn
14 Kruman II, Kumaravel TS, Lohani A, Pedersen WA, Cutler RG, Kruman Y, Haughey N, Lee J, Evans M, Mattson MP. Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease. J Neurosci 22(5): 1752-1762, 2002   DOI
15 Geller J, Kronn D, Jayabose S, Andoval C. Hereditary folate malabsorption. Medicine 81: 51-68, 2002   DOI   ScienceOn
16 van der Put NM, Steegers-Theunissen RP, Frosst P, Trijbels FJ, Eskes TK, van den Heuvel LP, Mariman EC, den Heyer M, Rozen R, Blom HJ. Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida. Lancet 346: 1070-1071, 1995   DOI   ScienceOn
17 Wang W, Kramer PM, Yang S, Pereira MA, Tao L. Reverse-phase high-performance liquid chromatography procedure for the simultaneous determination of S-adenosyl-L-methionine and S-adenosyl- L-homocysteine in mouse liver and the effect of methionine on their concentrations. Chromatogr. B. Biomed Sci Appl 762(1): 59-65, 2001   DOI
18 Surtees R, Clelland J, Hann I. Demyelination and single-carbon transfer pathway metabolites during the treatment of acute lymphoblastic leukemia: CSF Studies. J Clin Oncol 16(4): 1505-1511, 1998   DOI
19 Scott JM. Folate-vitamin B12 interrelationships in the central nervous system. Proc Nutr Soc 51: 219-224, 1992   DOI
20 Miller PN, Pratten MK, Beck F. Growth of 9.5-day rat embryos in folic-acid-deficient serum. Teratology 39(4): 375-385, 1989   DOI   ScienceOn
21 Magnaghi V, Veber D, Morabito A, Buccellato FR, Melcangi RC, Scalabrino G. Decreased GFAP-mRNA expression in spinal cord of cobalamin-deficient rats. FASEB express article 10.1096/fj.02- 0231 fje.September 19, 2002
22 Ghosh SK, Syed SK, Jung S, Paik WK, Kim S. Substrate specificity for myelin basic protein-specific protein methylase I. Biochim Biophysic Acta 1039: 142-148, 1990   DOI
23 Allen RH, Stabler SP, Lindenbaum J. Relevance of vitamins, homocysteine and other metabolites in neuropsychiatric disorders. Eur J Pediatr 157(2): 122-126, 1998   DOI   ScienceOn
24 Henning SM, McKee RW, Swendseid ME. Hepatic content of Sadenosylmethionine, S-adenosylhomocysteine and glutathione in rats receiving treatment modulating methyl donor availability. J Nutr 119(10): 1478-1482, 1989   DOI
25 Endres M, Ahmadi M, Kruman I, Biniszkiesicz D, Meisel A, Gertz K. Folate deficiency increases postischemic brain injury. Stroke 36: 321-325, 2005   DOI   ScienceOn
26 Durga J, Botsc ML, Schoutena EG, Koka FJ, Verhoefa P. Low concentrations of folate, not hyperhomocysteinemia, are associated with carotid intima-media thickness. Atherosclerosis 179(2): 285-292, 2005   DOI   ScienceOn
27 Gilles FH, Leviton A, Dooling FC, Editors. The Developing Human Brain Growth and Epidemiologic Neuropathology, pp.117- 183, John Wright,Inc., Boston, 1983
28 Kruger GM, Diemel LT, Copelman CA, Cuzner ML. Myelin basic protein isoforms in myelinating and remyelinating rat brain aggregate cultures. J Neurosci Res 56: 241-247, 1999   DOI   ScienceOn
29 Kim YI, Pogribny IP, Basnakian AG, Miller JW, Selhub J, James SJ, Masmon JB, Folate deficiency in rats induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene. Am J Clin Nutr 65(1): 46-52, 1997   DOI
30 Fernstrom JD. Can nutrient supplements modify brain function? Am J Clin Nutr 71(1): 1669S-1673S, 2000
31 Rosenquist TH, Ratashak SA, Selhub J. Homocysteine induces congenital defects of the heart and neural tube: Effect of folic acid. Proc Natl Acad Sci USA 93: 15227-15232, 1996