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The Relationship between Some Blood Parameters and Antioxidant Enzyme Activity in Korean Postmenopausal Women  

Lee, Haeng-Shin (Department of Food Industry, Korea Health Industry Development Institute)
Kim, Mi-Hyun (Department of Food & Nutrition, Kangwon National University)
Lee, Da-Hong (Department of Food & Nutrition, Wonkwang University)
Sung, Chung-Ja (Department of Food & Nutrition, Sookmyung Womnen's University)
Publication Information
Journal of Nutrition and Health / v.39, no.5, 2006 , pp. 476-484 More about this Journal
Abstract
To elucidate the relationship between blood parameters related bone metabolism and antioxidant enzyme activity in postmenopausal period 60 women residing in Iksan area were recruited. Food and nutrient intake of each individual subject were estimated by 24-hour recalls of 3 non-consecutive days. The biochemical markers including total protein, albumin, osteocalcin (intact bone gla protein; BOP), calcium, phosphorus and hemoglobin were measured in fasting blood. In addition, parameters of antioxidative capacity including the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx) , catalase (CAT) and total antioxidant capacity (TA) were monitored in blood, also. The mean age, height, weight, and BM! of subjects were 64.8 years, 151.1 em, 59.5 kg $26.0\;kg/m^2$, respectively. The mean SOD, GPx, and CAT activities were 138.5 U/ml, 1,273.8 U/ml and 314.3 kU/l respectively, and TA was 1.16 mmol/l without significant difference among different age groups. BMI was positively correlated with SOD activity (p < 0.01). SOD activity and CAT activity showed positive correlation with serum albumin (p < 0.05) and hemoglobin (p < 0.01). In conclusion, this study revealed that antioxidant enzyme activity holds a significant relationship with the blood parameters like as serum albumin and hemoglobin in postmenopausal women and further systematic research is needed to investigate the their relation mechanism.
Keywords
superoxide dismutase; blood parameters; postmenopausal women; antioxidant enzyme;
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1 Schulz H. Regulation of fatty acid oxidation in heart. J Nutr 124: 165-171, 1994   DOI
2 Veille JC, Li P, Eisenach JC, Massmann AG, Figueroa JP. Effects of estrogen on nitric oxide biosynthesis and vasorelaxant activity in sheep uterine and renal arteries in vitro. Am J Obstet Obstet 174: 1043-1049, 1996   DOI
3 Damoulis PD, Hauschka PV. Cytokines induce nitric oxide production in mouse osteo-blasts. Biochem Biophys Res Commun 201: 924-931, 1994   DOI   ScienceOn
4 Ralston SH, Todd D, Helfrich MH, Benjamin N, Grabowski P. Human osteoblast-like cells produce nitric oxide and express inducible nitric oxide synthase. Endocrinology 135: 330-336, 1994   DOI   ScienceOn
5 Schurman L, Sedlinsky C, Mangano A, Sen L, Leiderman S, Fernandez G, Theas S, Damilano S, Gurfinkel M, Seilicovich A. Estrogemic status influences nitric oxide-regulated TNF-alpha release from human peripheral blood monocytes. Exp Clin Endocrino Diabetes 109: 340-344, 2001   DOI   ScienceOn
6 Gutteridge JM. Iron promoters of th Fenton reaction and lipid peroxidation can be released from hemoglobin by peroxides. FEBS Lett 201: 291-295, 1986   DOI   ScienceOn
7 Harel S, Salan MA, Kanner J. Iron release from metmyoglobin, methaemoglobin and cytochrom c by a system generating hydrogen peroxide. Free Radic Res Commun 5: 11-19, 1988   DOI
8 WHO/ISH 세계보건기구 및 국제 고혈압 학회의 지침. 1999 World Health Organization, 1999
9 Kim MH. The Study of Relationship among Serum Leptin, Nutritional Status, Serum Glucose and Lipids of Middle School Girls. Korean J of Nutri 33: 49-58, 2000
10 Chung YS, Song MK, Park DB, Kim HM, Lim YA, Kwak YS, Lee DJ. Comparison of Biochemical Bone Markers in Postmenopausal women. Korean J Bone Metab 2: 120-126, 1995
11 Sung CJ, Back SK, Lee HS, Kim MH, Choi SH, Lee SY, Lee DH. A study of Body Anthropometry and Dietary Factors Affecting Bone Mineral Density in Korean pre- and postmenopausal Women. J Korean Society of Food Science and Nutrition 30: 159-167, 2001
12 Viroonudomphol D, Pongpaew P, Tungtrongchitr R, Phonrat B, Supawan V, Vudhivai N, Schelp FP. Erythrocyte antioxidant enzymes and blood pressure in relation to overweight and obese Thai in Bangkok. Southeast Asian J Trop med Public Health 31: 325-334, 2000
13 Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70: 158-169, 1967
14 Floh L, Becker R, Brigelius R, Lengfelder E, tting F. Convenient Assasy for Superoxide Dismutase. CRC Handbook of free Radicals and Antioxidants in Biomedicine, pp.287-293, 1992
15 Recommended dietary allowances for Koreans, 8th revision, The Korean Nutrition Society, Seoul, 2005
16 Kim SK, Park YS, Byoun KE. Comparison of the Total Antioxidant Status and Usual Dietary Intake in Normal and Overweight Males. Korean J of Community Nutrition 5: 633-641, 2000
17 Choi EJ, Lee HO. Influencing Factors on the Bone Status of Rural Menopausal Women. Korean J of Nutri 29: 1013-1020, 1996
18 Life-table. Korea National Statistical Office, 2005
19 Iseri SO, Sener G, Yuksel M, Contuk G, Cetinel S, Gedik N, Yegen BC. Ghrelin against alendronate- induced gastric damage in rats. J Endocrinol 187: 399-406, 2005   DOI   ScienceOn
20 The Korean nutrition Society, Computer aided nutritional analysis program Version 2.0, The Korean nutrition Society, 2000
21 Chung KW, Kim MR, Rye SW, Kwon DJ, Kim JH, Lim YT, Lee JW. The Predictive value of Biochemical Markers of Bone Turnover for Bone Mineral Density in Peri and Postmenopausal women. 5: 55-63, 1999   DOI
22 Thomas MJ. The role of free radicals and antioxidants: How do we know hat they are working. Crit Rev Food Sci Nutr 35: 21-39, 1995   DOI   ScienceOn
23 Stacey E, Korkia P, Hukkanen MV, Polak J, Rutherford OM. Decreased nitric oxide levels and bone turnover in amenorrheic athletes with spinal osteopenia. J Clin Endocrinol Metab 83: 3056-3061, 1998   DOI   ScienceOn
24 Hong JY, Cho YW, Back JY, Cho HJ, Song YB. The Study of Correlation between Serum Vitamin K Concentration and Bone Metabolism in postmenopausal Women. Korean J of Nutri 32: 287-295, 1999
25 Park JW, Parj JG, Ihm CB, Rheem IS, Kwon KC, Kim JW. Relationship of Free Fatty Acid/ Albumin Molar Ratio with Indicators of Erythrocyte Injury in Clinical Conditions with Hypoalbuminemia. Korean J Clin Pathol 18: 321-327, 1998
26 Halliwell B, Murcia MA, Chirico S, Aruoma OI. Free radicals and antioxidants in food and in vivo: What they do and how they work. Crit Rev Food Sci Nutr 35: 7-20, 1995   DOI   ScienceOn
27 Garrett IR, Boyce BF, Oreffo ROC, Bonewald L, Poser J, Mundy GR. Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo. J Clin Invest 85: 632-639, 1990   DOI
28 Kim HM, Han IK, Cho NH. The Effect of Parity on Bone Metabolism in Korean Women: A- Cross- Sectional Study. The Korean Society Menopause 4: 16-24, 1998
29 Zayzafoon M, Meyers VE, McDonald JM. Microgravity: the immune response and bone. Immunol REV 208: 267-280, 2005   DOI   ScienceOn
30 Lee BK. Study on the ecological factors affecting bone mass density in post-menopausal women. Thesis. Hanyang Graduate School, 1992
31 Kim YJ, Yokozawa T, Chung HY. Suppression of oxidative stress in aging NZB/NZW mice: effect of fish oil feeding on hepatic antioxidant status and guanidino compounds. Free Radic Res 39: 1101-1110, 2005   DOI   ScienceOn
32 Ahn KS, Aggarwal BB. Transcription Factor NF-{Kappa} B: A Sensor for Smoke and Stress Signals. Ann N Y Acad Sci 1056: 218-233, 2005   DOI
33 Tapan KB, Norman JT, Manohar LG. Antioxidants in human health and diseaes. CAB International, London, UK, 1999
34 Aruoma OI, Halliwell B. Superoxide-dependent and ascorbatedependent formation of hydroxyl radicals from hydrogen peroxide in the presence of iron. Are lactoferrin and ferrin promoters of hydroxy-radical generation? Biochem J 241: 273-278, 1987   DOI
35 Won Yj, Lim SG, Kwon SH, Cha BS, Nam SY, Lee JH, Song YD, Kim KR, Lee HC, Huh KB, Chung BC. A Study About Correlation Between Uninary Androgen Metabolites and Bone Mineral Density in Postmenopausal Women. The Korean Society Endocrinology 12: 450-461, 1997
36 Collin-Osdby P, Rothe L, Bekker S, Anderson F, Osdoby P. Decreased nitric oxide levels stimulate osteoclastogenesis and bone resorption both in vitro and in vivo on the chick chorioallantoic membrane in association with neoangiogenesis. J Bone Miner Res 15: 474-488, 2001   DOI   ScienceOn
37 Datta HK, Rathod H, Manning P, Turnbull Y, McNeil CJ. Parathyroid hormone induces superoxide anion burst in the osteoclast: evidence for the direct instantaneous activation of the osteoclast by the hormone. Endocrinology 149: 269-275, 1996   DOI
38 Wimalawansa SJ, De Marco G, Grngula P, Yallampalli C. Nitric oxide donor alleviates ovariectomy-induced bone loss. Bone 18: 301-304, 1996   DOI   ScienceOn
39 Lee HJ, Lee EG. Bone Mineral Density of Korean Motherdaughter pairs: Relations to Anthropometric Measurement, Body Composition, Bone Markers, Nutrient intakes and Energy Expenditure. Korean J of Nutri 29: 991-1002, 1996
40 Sharma S, Kaur IP. Development and evaluation of seasamol as an antiaging agent. Int J Dermatol 45: 200- 208, 2006
41 Aebi H. Catalse. In 'Methods of Enzymatic Analysis' Bergmeyer HU (ed.), Chemie, Weinheim, F.R.G., p.673, 1974
42 Ministry of Health and Welfare. 2001 National Nutrition Survey Report, 2002