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The Effect of Caffeine on 3T3-L1 Adipocyte Differentiation : A Nutrigenomical Approach  

Kim Mi-Ja (Department of Obesity Management, Dongduk Women's University, Imagine Obesity Research Institute)
Kim Youngok (Department of Food and Nutrition, Dongduk Women's University)
Chung Joo-HO (Department of Pharmacology, College of Medicine, Kyung Hee University)
Kim Jong-Woo (Imagine Obesity Research Institute, Department of Neuropsychiatry, College of Medicine, Kyung Hee University)
Kim Hye-Kyung (Department of Food and Biotechnology, Hanseo University)
Publication Information
Journal of Nutrition and Health / v.38, no.8, 2005 , pp. 649-655 More about this Journal
Abstract
Nutrigenomics refers to research that investigates the interaction between nutrition and the human genome. Caffeine in tea and coffee is widely and routinely consumed by people. This study was performed to confirm the effect of caffeine treatment on the gene expression and cytokine profiling in 3T3-L1 adipocyte cells using microarray and protein array methodology. Treatment of caffeine in 3T3-L1 adipocyte cells increased expression of several genes related with obesity including adipocyte C1Q and collagen domain containing (ACDC), Adipsin (ADN), uncoupling protein 3(UCP3), while glyceraldehyde-3-phosphate dehydrogenase (GAPDH), which is known as lipid storage enzyme, was decreased by caffeine treatment. Furthermore, cytokines, such as interleukin-3 (IL-3), interleukin-12(IL-12), interleukin-13 (IL-13), granulocyte colony stimulating factor (GCSF), granulocyte macrophage colony stimulating factor (GM-CSF) and vascular endothelial growth factor (VEGF), were decreased in caffeine treated 3T3-L1 adipocyte cells. These results provided interesting information about the genes related with caffeine and cytokine expression profiling in obesity.
Keywords
nutrigenomics; caffeine; 3T3-L1; obesity;
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