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LDL Oxidation, Total Radical Trapping Antioxidant Potential and Plasma Antioxidant Vitamin Systems in Obese School Children  

Shin Min-Jeong (Yonsei Cardiovascular Research Institute, Yonsei University College of Medicine)
Jun Kyung-Im (Department of Food and Nutrition, Kyungnam University)
Seo Bo-Young (Department of Food and Nutrition, Kyungnam University)
Park Eunju (Department of Food and Nutrition, Kyungnam University)
Publication Information
Journal of Nutrition and Health / v.38, no.7, 2005 , pp. 553-560 More about this Journal
Abstract
The purpose of this study was to examine the lipid peroxidation, plasma antioxidant status and insulin resistance in childhood obesity. To this end, we measured blood lipid profiles, glucose, insulin concentrations, plasma antioxidant vitamins, baseline conjugated diene formation as a measure of LDL oxidation in vivo and TRAP (total radical trapping antioxidant potential) of 93 school children (58 nonobese, 35 overweight-obese). Insulin resistance was estimated by homeostasis model assessment of insulin resistance (HOMA-IR). The overweight-obese children showed significantly higher levels of leptin (p < 0.0001) and triglyceride (p < 0.05) and significantly lower level of plasma Iycopene (p < 0.001) and $\gamma$-tocopherol (p < 0.05) compared with the normal weight children. Furthermore, the levels of TRAP were significantly lower in overweight-obese children (p < 0.05). Significant positive relationships between plasma leptin and conjugated dienes formation (p < 0.005) and inverse relationship between plasma leptin and lipid corrected levels of $\beta$-carotene (p < 0.05), Iycopene (p < 0.05) were observed. Our results showed an increased lipid peroxidation and decreased antioxidant capacity in childhood obesity which could be involved in the atherosclerotic process.
Keywords
childhood obesity; total radical-trapping antioxidant potential; lipid peroxidation; antioxidant vitamins; insulin resistance;
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