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The Study on the Serum Levels of Resistin, Adiponectin, and Leptin in Obese Children  

Lee Hyun Sook (Department of Sports Science, Seoul Sports Graduate University)
Choi Jin Sun (Department of Food and Nutrition, Ewha Womans University)
Kim Wha Young (Department of Food and Nutrition, Ewha Womans University)
Publication Information
Journal of Nutrition and Health / v.38, no.3, 2005 , pp. 197-202 More about this Journal
Abstract
Resistin, adiponectin, and leptin are hormones secreted by adipose tissue and are known to play an important role in adipose tissue metabolism. The purpose of this study was to evaluate the levels of adipocyte-derived hormones (resistin, adiponectin, leptin) in obese children aged 10-12 years. The subjects were 102 obese children with obesity index (OI) over $120\%$ and 51 control children with obesity index less than $120\%$ were included for comparison. Anthropometric variables and serological parameters were assessed. Height, weight, OI, body mass index (BMI) were significantly higher in obese group than in control. Obese children showed significantly higher serum concentrations of triglyceride (TG), total cholesterol (TC), and LDL-cho1esterol and significantly lower HDL-cholesterol compared with control children, even though the values were within normal ranges for both groups. Concentrations of resistin and leptin were significantly higher in obese group than in control. Adiponectin and insulin levels were tended to lower in obese group even though the differences were not statistically significant. Resistin had significant positive correlation with OI and TG, and 1eptin with weight, OI, BMI, TG and TC. On the other hand, adiponectin showed significant negative correlations with height, OI and BMI. These finding showed that obese children had higher serum levels of resistin and leptin and lower adiponectin, and also these hormones had correlations with related factors of obesity, suggesting adipocyte-derived hormones has a role in child obesity.
Keywords
obesity; resistin; adiponectin; leptin; insulin;
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1 Must A, Strauss RS. Risks and consequences of childhood and adolescent obesity. Int J Obes Relat Metab Disord 23 (Suppl 2) : S2-11, 1999
2 Milan G, Granzotto M, Scarda A, Calcagno A, Pagano C, Federspil G, Vettor R. Resistin and adiponectin expression in visceral fat of obese rats: effect of weight loss. Obes Res 10(11): 1095-1103, 2002   DOI   ScienceOn
3 Fukui Y, Motojima K. Expression of resistin in the adipose tissue is modulated by various factors including peroxisome proliferator-activated receptor alpha. Diabetes Obes Metab 4 (5): 342-345, 2002   DOI   ScienceOn
4 Berg AH, Combs TP, Du X, Brownlee M, Scherer PE. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 7 (8): 947-953, 2001   DOI   ScienceOn
5 Youn BS, Yu KY, Park HJ, Lee NS, Min SS, Youn MY, Cho YM, Park YJ, Kim SY, Lee HK, Park KS. Plasma resistin concentrations measured by enzyme-linked immunosorbent assay using a newly developed monoclonal antibody are elevated in individuals with type 2 diabetes mellitus. J Clin Endocrinol Metab 89 (1): 150-156, 2004   DOI   ScienceOn
6 Ouehi N, Kihara S, Arita Y, Maeda K, Kuriyama H, Okamoto Y, Hotta K, Nishida M, Takahashi M, Nakamura T, Yamashita S, Funahashi T, Matsuzawa Y.Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Crculation 100(25): 2473-2476, 1999   DOI
7 Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF. A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 270 (45): 26746-26749, 1995   DOI   ScienceOn
8 Chu NF, Chang JB, Shieh SM. Plasma leptin, fatty acids, and tumor necrosis factor-receptor and insulin resistance in children. Obes Res 11 (4): 532-540, 2003   DOI   ScienceOn
9 Kang YJ, Hong CH, Hong YJ. The prevalence of Childhood and Adolescent Obesity Over the Last 18 Years in Seoul Area. Kor J Nutr 30 (7): 832-839, 1997
10 Busanmetropolitan City Office Education. Research on obese children, 2001
11 Weyer C, Funahashi T, Tanaka S, Hotta K, Matsuzawa Y, Pratley RE, Tataranni PA. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 86(5): 1930-1935, 2001   DOI   ScienceOn
12 Asayama K, Hayashibe H, Dobashi K, Uchida N, Nakane T, Kodera K, Shirahata A, Taniyama M .Decrease in serum adiponectin level due to obesity and visceral fat accumulation in children. Obes Res 11 (9): 1072-1079, 2003   DOI   ScienceOn
13 Kennedy GC. The role of depot fat in the hypothalamic control of food intake in the rat. Proc R Soc Land B Biol Sci 140 (901) : 578-596, 1953
14 Ravussin E, Pratley RE, Maffei M, Wang H, Friedman JM, Bennett PH, Bogardus C. Relatively low plasma leptin concentrations precede weight gain in Pima Indians. Nat Med 3 (2) : 238-240, 1997   DOI   ScienceOn
15 Azuma K, Katsukawa F, Oguchi S, Murata M, Yamazaki H, Shimada A, Saruta T. Correlation between serum resistin level and adiposity in obese individuals. Obes Res 11 (8): 997-1001, 2003   DOI   ScienceOn
16 Steppan CM, Lazar MA. Resistin and obesity-associated insulin resistance. Trends Endocrinol Metab 13 (1): 18-23, 2002   DOI   ScienceOn
17 Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259 (5091): 87-91, 1993   DOI   PUBMED   ScienceOn
18 Pelleymounter MA, Cullec MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F. Effect of the obese gene product on body weight regulation in ob/ob mice. Science 269: 540-543, 1995   DOI   PUBMED
19 Okamoto Y, Kihara S, Ouchi N, Nishida M, Arita Y, Kumada M, Ohashi K, Sakai N, Shimomura I, Kobayashi H, Terasaka N, Inaba T, Funahashi T, Matsuzawa Y. Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice. Circulation 106 (22): 2767-2770, 2002   DOI   ScienceOn
20 Valle M, Gascon F, Martos R, Bermudo F, Ceballos P, Suanes A. Relationship between high plasma leptin concentrations and metabolic syndrome in obese pre-pubertal children. Int J Obes Relat Metab Disord 27 (1): 13-18, 2003   DOI   ScienceOn
21 Stefan N, Bunt JC, Salbe AD, Funahashi T, Matsuzawa Y, Tataranni PA. Plasma adiponectin concentrations in children: relationships with obesity and insulinemia. J Clin Endocrinol Metab 87 (10) : 4652-4656, 2002   DOI   ScienceOn
22 Steinberger J, Steffen L, Jacobs DR Jr, Moran A, Hong CP, Sinaiko AR. Relation of leptin to insulin resistance syndrome in children. Obes Res 11 (9): 1124-1130, 2003   DOI   ScienceOn
23 Pi-Sunyer FX. Medical hazards of obesity. Ann Intern Med 119(2): 655-660, 1993   DOI
24 National cholesterol Education Program: Report of the expert panel on blood cholesterol levels in children and adolescents. Pediatrics 89 (Suppl.) : 523-576, 1992
25 Ahren B, Larsson H, Whihelmsson C. Regulation of circulating leptin levels in humans, Endocrinology 7: 1-7, 1997   DOI
26 Heilbronn LK, Rood J, Janderova L, Albu JB, Kelley DE, Ravussin E, Smith SR. Relationship between serum resistin concentrations and insulin resistance in nonobese, obese, and obese diabetic subjects. J Clin Endocrinol Metab 89 (4): 1844-1848, 2004   DOI   ScienceOn
27 Moore GB, Chapman H, Holder JC, Lister CA, Piercy V, Smith SA, Clapham JC. Differential regulation of adipocytokine mRNAs by rosiglitazone in db/db mice. Biochem Biophys Res Commun 286(4): 735-741, 2001   DOI   ScienceOn
28 Hotta K, Funahashi T, Bodkin NL, Ortrneyer HK, Arita Y, Hansen BC, Matsuzawa Y. Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 50(5): 1126-1133, 2001   DOI   ScienceOn
29 Shojima N, Sakoda H, Ogihara T, Fujishiro M, Katagiri H, Anai M, Onishi Y, Ono H, Inukai K, Abe M, Fukushima Y, Kikuchi M, Oka Y, Asano T. Humoral regulation of resistin expression in 3T3-L1 and mouse adipose cells. Diabetes 51(6): 1737-1744, 2002   DOI   ScienceOn
30 Chandran M, Phillips SA, CiaraIdi T, Henry RR. Adiponectin: more than just another fat cell hormone? Diabetes Care 26 (8) : 2442-2450, 2003   DOI   ScienceOn
31 Degawa- Yamauchi M, Bovenkerk JE, Iuliar BE, Watson W, Kerr K, Iones R, Zhu Q, Considine RY. Serum resistin (FIZZ3) protein is increased in obese humans. J Clin Endocrinol Metab 88(11): 5452-5455, 2003   DOI   ScienceOn
32 Lee JH, Chan JL, Yiannakouris N, Kontogianni M, Estrada E, Seip R, Orlova C, Mantzoros CS. Circulating resistin levels are not associated with obesity or insulin resistance in humans and are not regulated by fasting or leptin administration: cross-sectional and interventional studies in normal, insulin-resistant, and diabetic subjects. J Clin Endocrinol Metab 88 (10): 4848-4856, 2003   DOI   ScienceOn
33 Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS, Lazar MA. The hormone resistin links obesity to diabetes. Nature 409(6818): 307-312, 2001   DOI   ScienceOn
34 Way JM, Gorgun CZ, Tong Q, Uysal KT, Brown KK, Harrington WW, Oliver WR Jr, Willson TM, Kliewer SA, Hotamisligil GS. Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists. J Biol Chem 276 (28): 25651-25653, 2001   DOI   ScienceOn
35 Chessler SD, Fujimoto WY, Shofer JB, Boyko EJ, Weigle DS. Increased plasma leptin levels are associated with fat accumulation in Japanese Americans. Diabetes 47 (2): 239-243, 1998   DOI   ScienceOn
36 Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM. Weightreducing effects of the plasma protein encoded by the obese gene. Science 269 (5223) : 543-546, 1995   DOI   PUBMED
37 Friedwald WT, Levy RI, Fredireck DS. Estimation of the concen-tration of low density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin Chern 18: 499-502, 1972
38 Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shimomura I, Nakamura T, Miyaoka K, Kuriyama H, Nishida M, Yamashita S, Okubo K, Matsubara K, Muraguchi M, Ohmoto Y, Funahashi T, Matsuzawa Y. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 257 (1) : 79-83, 1999   DOI   ScienceOn