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The Effects of Purple Grape Juice Supplementation on Blood Pressure, Plasma Lipid Profile and Free Radical Levels in Korean Smokers  

김정신 (한남대학교 이과대학 식품영양학과)
김혜영 (한남대학교 이과대학 식품영양학)
박유경 (한남대학교 이과대학 식품영양학)
박은주 (경남대학교 생명과학)
강명희 (한남대학교 이과대학 식품영양학과)
Publication Information
Journal of Nutrition and Health / v.37, no.6, 2004 , pp. 455-463 More about this Journal
Abstract
Flavonoids contained in grapes are potent antioxidants that may protect against oxidative stress and reduce the risk of chronic diseases related with free radical damage. In this study we investigated the effect of daily grape juice supplementation on blood pressure (BP), plasma lipid profiles and the generation of free radicals in 67 healthy volunteers (29 smoker, 38 nonsmokers). The daily 480 ml of grape juice supplementation for 8 weeks resulted in a significant decrease in diastolic BP by 6.5％ in smokers and systolic and diastolic BP by 11.2 and 3.7％ in non-smokers. Plasma total cholesterol, HDL- and LDL-cholesterollevels in smokers and total cholesterol in non-smokers were significantly increased after the intervention. Plasma triglycerides and conjugated dienes were not affected by grape juice supplementation. Levels of free radical determined by reading the lucigenin-perborate ROS generating sources, decreased significantly by 18％ compared to the beginning of the study. The results indicated that the consumption of grape juice may reduce BP and free radical generation in smokers, which was possibly exerted by flavonoids. Our findings suggested that the grape juice has protective effect on chronic disease due to the overproduction of free radical in smokers.
Keywords
grape juice; supplementation; free radical; smokers; blood pressure; lipid profitl;
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