Preparation and in vivo Evaluation of a Sildenafil Lactate-loaded Solid Self-emulsifying Drug Delivery System |
Jung, Si-Young
(College of Pharmacy, Yeungnam University)
Kim, Dong-Wuk (College of Pharmacy, Hanyang University) Lee, Dong-Won (College of Pharmacy, Yeungnam University) Woo, Jong-Soo (Pharmaceutical Research Center, Hanmi Pharm. Co.) Kim, Jong-Oh (College of Pharmacy, Yeungnam University) Yong, Chul-Soon (College of Pharmacy, Yeungnam University) Choi, Han-Gon (College of Pharmacy, Hanyang University) |
1 | Wang, Y., Chow, M.S., Zuo, Z., 2008. Mechanistic analysis of pHdependent solubility and trans-membrane permeability of amphoteric compounds: application to sildenafil. Int. J. Pharm. 352, 217-224. DOI |
2 | Gratz, S.R., Flurer, C.L., Wolnik, K.A., 2004. Analysis of undeclared synthetic phosphodiesterase-5 inhibitors in dietary supplements and herbal matrices by LC-ESI-MS and LC-UV. J. Pharm. Biomed. Anal. 36(3), 525-533. DOI |
3 | Jung, S.J., Seo, Y.G., Kim, G.K., Woo, J.S., Yong, C.S., Choi, H.G., 2011. Comparison of the solubility and pharmacokinetics of sildenafil salts, Arch. Pharm. Res. 34(3) 451-454. DOI |
4 | Li, D.X., Han, M.J., Balakrishnan, P., Yan, Y.D., Oh, D.H., Joe, J.H., Seo, Y.G., Kim, J.O., Park, S.M., Yong, C.S., Choi, H.G., 2010. Enhanced oral bioavailability of flurbiprofen by combined use of micelle solution and inclusion compound. Arch. Pharm. Res. 33, 95-101. 과학기술학회마을 DOI |
5 | Nichols, D.J., Muirhead, G.J., Harness, J.A., 2002. Pharmacokinetics of sildenafil after single oral doses in healthy male subjects: absolute bioavailability, food effects and dose proportionality. Br. J. Clin. Pharmacol. 53 (Suppl 1), 5S-12S. DOI |
6 | Quintero, A., Caldera, A., Milano, B., Odreman, I., Hurtado, A., Manzanares, L., Villamizar, J., 2009. Validation of an HPLC method for sildenafil citrate analysis in human plasma samples. Pharmazie 64(12), 796-799. |
7 | Shah, N.H., Carvajal, M.T., Patel, C.I., Infeld, M.H., Malick, A.W., 1994. Self-emulsifying drug delivery systems (SEDDS) with polyglycolyzed glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs. Int. J. Pharm. 106, 15-23. DOI |
8 | Shin, H.S., Bae, S.K., Lee, M.G., 2006. Pharmacokinetics of sildenafil after intravenous and oral administration in rats: Hepatic and intestinal first-pass effects. Int. J. Pharm. 320, 64-70. DOI |
9 | Society of Toxicology (SOT), 2008. Guiding Principles in the Use of Animals in Toxicology. www.toxicology.org/AI/FA/guidingprinciples.pdf |
10 | Amidon, G.L., Lennernas, H., Shah, V.P., Crison, J.R., 1995. A theoretical basis for a biopharmaceutics drug classification : the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm. Res. 12, 413-420. DOI |
11 | Balakrishnan, P., Lee, B.J., Oh, D.H., Kim, J.O., Lee, Y.I., Kim, D.D., Jee, J.P., Lee, Y.B., Woo, J.S., Yong, C.S., Choi, H.G., 2009. Enhanced oral bioavailability of Coenzyme Q10 by selfemulsifying drug delivery systems. Int. J. Pharm. 374, 66-72. DOI ScienceOn |
12 | Boolell, M., Gepi-Attee, S., Gingell, J.C., Allen, M.J., 1996. Sildenafil, a novel effective oral therapy for male erectile dysfunction. Br. J. Urol. 184, 63-72. |
13 | Choi, H.G., Oh, Y.K., Kim, C.K., 1998. In-situ gelling and mucoadhesive liquid suppository containing acetaminophen: enhanced bioavailability. Int. J. Pharm. 165, 23-32. DOI |
14 | Eardly, I., Ellis, P., Boolell, M., Wulff, M., 2002. Onset and duration of action of sildenafil citrate treatment of erectile dysfunction. Br. J. Clin. Pharmacol. 53, 61S-65S. DOI |
15 | Elshafeey, A.H., Bendas, E.R., Mohamed, O.H., 2009. Intranasal microemulsion of sildenafil citrate: in vitro evaluation and in vivo pharmacokinetic study in rabbits. AAPS PharmSciTech. 10(2), 361-367. DOI |
![]() |