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http://dx.doi.org/10.4333/KPS.2010.40.5.277

Enhanced Dissolution of Coenzyme Q10 using Solid Dispersions Prepared by Low Temperature Melting Method  

Kang, Jun-Heok (College of Pharmacy, Yeungnam University)
Yan, Yi-Dong (College of Pharmacy, Yeungnam University)
Kim, Hyun-Chan (College of Pharmacy, Yeungnam University)
Lee, Sung-Neung (College of Pharmacy, Yeungnam University)
Yong, Chul-Soon (College of Pharmacy, Yeungnam University)
Choi, Han-Gon (College of Pharmacy, Yeungnam University)
Publication Information
Journal of Pharmaceutical Investigation / v.40, no.5, 2010 , pp. 277-283 More about this Journal
Abstract
CoQ with low melting temperature was exploited to improve its solubility by preparing its solid dispersions (SDs) with a meltable polymer, poloxamer 407 (P 407). P407 can be utilized for a relatively simple, quick, inexpensive, reproducible and potentially scalable manner in the low temperature melting method. CoQ 10 solubility and dissolution increased with increasing concentrations of P 407 in SDs. Comparison of the enhanced dissolution of CoQ 10 from different poloxamers suggested that the preparation of CoQ 10 SDs using P 407 as a meltable hydrophilic polymer carrier could be a promising approach to improve its dissolution.
Keywords
Coenzyme Q10; Poloxamer 407; Solid dispersion; Solubility; Dissolution;
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Times Cited By KSCI : 1  (Citation Analysis)
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1 Weis, M., Mortensen, S.A., Rassing, M.R., Moller, S.J., Poulsen, G., Rasmussen, S.N., 1994. Bioavailability of four oral coenzyme Q10 formulations in healthy volunteers, Mol. Aspects Med., 15(suppl): S273-280.   DOI   ScienceOn
2 Yu, H., Chun, M.K., Choi, H.K., 2007. Preparation and characterization of piroxicam/poloxamer solid dispersion prepared by melting method and solvent method. J. Kor. Pharm. Sci., 37, 1-5.
3 Mura, P., Manderioli, A., Bramanti, G., Ceccarelli, L., 1996. Properties of solid dispersions of naproxen in various polyethylene glycols, Drug Dev. Ind. Pharm., 22, 909-916.   DOI
4 Ozawa, Y., Mizushima, Y., Koyama, I., 1986. Intestinal absorption enhancement of coenzyme Q10 with lipid microsphere, Drug Res., 36, 689-690.
5 Passerini, N., Albertini, B., Perissutti, B., Rodriguez, L., 2006. Evaluation of melt granulation and ultrasonic spray congealing as techniques to enhance the dissolution of praziquantel, Int. J. Pharm., 318, 92-102.   DOI
6 Passerini, N., Gonzalez-Rodriguez, M.L., Cavallari, C., Rodriguez, L., Albertini, B., 2002. Preparation and characterisation of ibuprofen- poloxamer 188 granules obtained by melt granulation, Eur. J. Pharm. Sci., 15, 71-78.   DOI
7 Rouchotas, C., Cassidy, O.E., Rowley, G., 2000. Comparison of surface modification and solid dispersion techniques for drug dissolution, Int. J. Pharm., 195, 1-6.   DOI   ScienceOn
8 Rousseau, G., Varin, F., 1998. Determination of ubiquinone-9 and 10 levels in rat tissues and blood by high-performance liquid chromatography with ultraviolet detection, J. Chromatogr. Sci., 36, 247-52.   DOI   ScienceOn
9 Seo, A., Holm, P., Kristensen, H.G., Schaeer, T., 2003. The preparation of agglomerates containing solid dispersions of diazepam by melt agglomeration in a high shear mixer, Int. J. Pharm., 259, 161-171.   DOI
10 Serajuddin, A.T.M., 1999. Solid dispersion of poorly water-soluble drugs: early promises, subsequent problems, and recent breakthroughs, J. Pharm. Sci., 88, 1058-1066.   DOI
11 Shin, S.C., Cho, C.W., 1997. Physicochemical characterizations of piroxicam-poloxamer solid dispersion, Pharm. Dev. Technol., 2, 403-40.   DOI
12 Takada, M., Yuzuriha, T., Katayama, K.,Yamato, C., Koyama, N., 1985. Targeting of Coenzyme Q10 solubilized with soy lecithin to heart of guinea pigs, J. Nutr. Sci. Vitaminol., 31,115- 120.   DOI
13 Craig, D.Q.M., 1990. Polyethylene glycols and drug release, Drug Dev. Ind. Pharm., 16, 2501-2506.   DOI
14 Jones, M.C., Leroux, J.C., 1999. Polymeric micelles- a new generation of colloidal drug carriers, Eur. J. Pharm. Biopharm., 48, 101-111.   DOI
15 Craig, D.Q.M., 2002. The mechanisms of drug release from solid dispersions in water-soluble polymers, Int. J. Pharm., 231, 131-144.   DOI
16 Takeuchi, H., Sasaki, H., Niwa, T., Hino, T., Kawashima, Y., Uesugi, K., Ozawa, H., 1992. Improvement of photostability of ubidecarenone in the formulation of a novel powdered dosage form termed redispersible dry emulsion. Int. J. Pharm., 86, 25-33.   DOI
17 Vilhelmsen, T., Eliasen, H., Schaeer, T., 2005. Effect of a melt agglomeration process on agglomerates containing solid dispersions, Int. J. Pharm., 303, 132-142.   DOI   ScienceOn
18 Folkers, K., Wolaniuk, A., Vadhanavikit, S., Sakmato, N., Takemura, K., Baker, L., Richardson, P.C., 1986. Biomedical and clinical research on coenzyme Q10 with emphasis on cardiac patients, In: Folkers, K., Yamamura, Y. (Eds.), Biomedical and Clinical Aspects of Coenzyme Q, Vol.5. Elsevier, Amsterdam, pp. 375-391.
19 Greenberg, S., Fishman, W.H., 1990. Coenzyme Q10: A new drug for cardiovascular disease, J. Clin. Pharmacol., 30, 590-608.
20 Hsu, C.H., Cui, Z., Russell, J.M., Michael, J., 2003. Preparation and characterization of novel coenzyme Q10 nanoparticles engineered from microemulsion precursors, AAPS Pharm- SciTech. 4 (3), E32.   DOI
21 Kabanov, A.V., Batrakova, E.V., Alakhov, V.Y., 2002. Pluronic block copolymers as novel polymer therapeutics for drug and gene delivery, J. Contr. Rel., 82, 189-212.   DOI   ScienceOn
22 Kimura, A., Yamaguchi, H., Watanabe, K., Hayash, I.M., Awazu, S., 1986. Factors influencing the tissue distribution of cownzymq Q10 intravenously administered in an emulsion to rats; emulsifying agents and lipoprotein lipase activity, J. Pharmacol., 38, 659-662.   DOI
23 Kishi, H., Kanamori, N., Nishii, S., Hiraoka, E., Okamato, T., Kishi, T., 1984. In: Folkers, K., Yamamura, Y. (Eds.), Biomedical and Clinical Aspects of Coenzyme Q, Elsevier, Amsterdam, pp. 131-142.
24 Kommurur, T.R., Gurley, B., Khan, M.A., Reddy, I.K., 2001. Selfemulsifying drug delivery systems (SEDDS) of coenzyme Q10: formulation development and bioavailability assessment, Int. J. Pharm., 212, 233-246.   DOI
25 Lutka, A., Pawlaczyk, J., 1995. Inclusion complexation of coenzyme Q10 with cyclodextrins, Acta Pol. Pharm., 52, 379-386.
26 Collett, J.H., Popli, H., 2000. Poloxamers In: A. H. Kibbe, Editor, Handbook of Pharmaceutical Excipients (3rd Edition ed), Pharmaceutical Press, London. pp. 385-388.
27 Chen, Y., Zhang, G.G.Z., Neilly, J., Marsh, K., Mawhinney, D., Sanzgiri, Y.D., 2004. Enhancing the bioavailability of ABT - 963 using solid dispersion containing pluronic F -68, Int. J. Pharm., 286, 69-80.   DOI
28 Chopra, R.K., Goldman, R., Sinatra, S.T., Bhagavan, H.N., 1998. Relative bioavailability of coenzyme Q10 formulations in human subjects, Int. J. Vit. Nutr. Res., 68, 109-113.
29 Chutimaworapan, S., Ritthidej, G.C., Yonemochi, E., Oguchi, T., Yamamoto, K., 2000. Effect of water soluble carriers on dissolution characteristics of nifedipine solid dispersions, Drug Dev. Ind. Pharm., 26, 1141-1150.   DOI