Browse > Article
http://dx.doi.org/10.4333/KPS.2009.39.1.055

Efficacy of Hydrogel Patch in Wound Rat Model  

Oh, Seung-Seok (College of pharmacy, Kyungsung University)
Kim, Chul-Jun (TDS Pharm. Co. Ltd.)
Kim, Hee-Sook (Department of Fook Science and Biotechnology, Kyungsung University)
Shin, Young-Hee (College of pharmacy, Kyungsung University)
Publication Information
Journal of Pharmaceutical Investigation / v.39, no.1, 2009 , pp. 55-58 More about this Journal
Abstract
Sodium polyacrylate based hydrogel patch was prepared and its wound healing efficacy in comparison with control groups was evaluated in thermal burn wound ($200^{\circ}C$, 10 sec burn) and excision wound rat model. Cytotoxicity of gamma irradiated (25 kGy) hydrogel patch was investigated in human fibroblasts and showed no significant cytotoxicity. Wound closure rates (H50%) in hydrogel patch group and BAND-$AID^{(R)}$ treated group were faster than that of control group (uncovered open wound). Hydrogel patch showed an enhancement in wound healing process.
Keywords
Hydrogel Patch; Thermal Burn Model; Excision Wound Rat Model; Wound Healing;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 P. Johnson, D. Hansen, D. Matarazzo. L. Petterson, C. Swisher and A. Trappolini, Transderm Scop for prevention of motion sickness. N. Engl. J. Med., 311(7), 468-469, (1984).   DOI   ScienceOn
2 K. Kaminski, K. Zazakowny, K. Szczubialka and M. Nowakowska, pH-sensitive genipin-cross-linked chitosan microspheres for heparin removal. Biomacromolecules, 9, 3127-3132 (2008).   DOI   ScienceOn
3 T. Mosmann, Rapid colorimetric assay for cellular growth and survival ; Application to proliferation and cytotoxicity assays. J Immunol. Meth., 65, 55-63 (1983).   DOI   ScienceOn
4 D.P. Dressler, W.K. Barbee and R. Sprenger, The effect of Hydron burn wound dressing on burned rat and rabbit ear wound healing. J. Trauma, 20(12), 1024-1028 (1980).   DOI
5 상처치료용 하이드로겔제제, 특허등록번호10-0656458 (2006.12.13)
6 S.H. Ryu, Y.S. Jeon, M.J. Kwon, J.W. Moon, Y.S. Lee and G.S. Moon, Effect of kimchi extracts to reactive oxygen species in skin cell cytotoxicity. J. Korean Soc. Food Sci. Nutr., 26(5), 814-821 (1997).   과학기술학회마을
7 E.H. Lee, J.K. Lee, Y.K. Kim, K.S. Park, K.S. Ahn, K.M. Jung, J.H. Kwan, S.H. Lee, S.Y. Chung and J.T. Hong, Correlation between skin irritation and cytotoxicity of antiwrinkle agents. Yakhak Hoeji, 45(3) 310-319 (2001).
8 M. Choi and H.P. Ehrilich, U75412E, a lazaroid, prevents progressive burn ischemia in a rat burn model. Am. J. Pathol., 142(2), 519-528 (1993).
9 R. Eloy and A.M. Cornilac, Wound healing of burns in rats treated with a new amino acid copolymer membrane. Burns, 18(5), 405-411 (1992).   DOI   ScienceOn
10 F.C. Regas and H.P. Ehrlich, Elucidating the vascular response to burns with a new rat model. J. Trauma, 32(5), 557-563 (1992).   DOI
11 S.C. Chen, Y.C. Wu, F.L. Mi, Y.H. Lin, L.C. Yu and H.W. Sung, A novel pH-sensitive hydrogel composed of N,Ocarboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery. J. control release, 96, 285-300 (2004).   DOI   ScienceOn
12 T. Kuroda, T. Harada, H. Tsutsumi and M. Kobayashi, Hypernatremia deepens the demarcating borderline of leukocytic infiltration in the burn wound. Burns, 23(5), 432-437 (1997).   DOI   ScienceOn
13 D.H. Cho and Y.H. Shin, Studies on the Wound Healing by the PVA-soft hydrogel. Yakhak Hoeji, 48(1), 55-59 (2004).   과학기술학회마을