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http://dx.doi.org/10.4333/KPS.2009.39.1.019

Enhanced Transdermal Delivery of Furosemide from the EVA Matrix through the Rat Skin  

Chang, Ik-Hyeon (College of Pharmacy, Chonnam National University)
Cho, Hwa-Young (College of Pharmacy, Chonnam National University)
Noh, Jin-Hyung (College of Pharmacy, Chonnam National University)
Park, Jung-Chan (College of Pharmacy, Chonnam National University)
Park, Yong-Sun (College of Pharmacy, Chonnam National University)
Kim, Seong-Jin (School of Medicine, Chonnam National University)
Shin, Sang-Chul (College of Pharmacy, Chonnam National University)
Publication Information
Journal of Pharmaceutical Investigation / v.39, no.1, 2009 , pp. 19-21 More about this Journal
Abstract
This study was performed to examine the possibility of increasing the level of furosemide permeation from the ethylene-vinyl acetate (EVA) matrix through the skin by incorporating various enhancers in the EVA matrix. The effects of the enhancers on the level of furosemide permeation through the skin were evaluated using Franz diffusion cells with intact excised rat skins. The enhancers examined were the fatty acids (saturated, unsaturated), the pyrrolidones, the propylene glycol derivatives, the glycerides and the non-ionic surfactants. Among the enhancers used, polyoxyethylene-2-oleyl ether (a non-ionic surfactant) showed the best enhancement. The polyoxyethylene 2-oleyl ether as a permeation enhancer could be used for development of furosemide-EVA transdermal matrix system.
Keywords
Furosemide; Ethylene-vinyl acetate; Transdermal delivery; Penetration enhancer; Matrix; Skin permeation;
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