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http://dx.doi.org/10.4333/KPS.2008.38.4.249

Improved Dissolution of Solid Dispersed Atorvastatin Using Spray-Dryer  

Lee, Jun-Hee (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University)
Kim, Dae-Sung (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University)
Kim, Won (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University)
Park, Jong-Hak (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University)
Ahn, Sik-Il (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University)
Kim, Yun-Tae (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University)
Rhee, John-M. (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University)
Khang, Gil-Son (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University)
Publication Information
Journal of Pharmaceutical Investigation / v.38, no.4, 2008 , pp. 249-254 More about this Journal
Abstract
Solid dispersions of poorly water-soluble drug, atorvastatin, were prepared with Eudragit L100 to improve the solubility by spray dryer. To investigate the correlation between physicochemical properties and dissolution rate of solid dispersions, the samples were characterized by scanning electron microscopy (SEM), differential scanning calorimeter (DSC) and fourier transform infrared spectroscopy (FT-IR). SEM and DSC were found that atorvastatin is amorphous in the Eudragit L100 solid dispersion. FT-IR was used to analyze the salt formation by interaction between atorvastatin and Eudragit L100. The dissolution rate of solid dispersed atorvastatin was markedly increased compared to drug powder in stimulated intestinal juice (pH 6.8). Thus, the solid dispersed atorvastatin using the spray drying method with Eudragit L100 may be effective for the bioavailability.
Keywords
Atorvastatin calcium; Solid dispersion; Spray dryer$Eudragit^{(R)}$ L100; Dissolution;
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Times Cited By KSCI : 6  (Citation Analysis)
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