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http://dx.doi.org/10.4333/KPS.2008.38.4.229

Temperature-Sensitive Drug Delivery System of Acetaminophen Using Neutral Chitosan Solution  

Kim, Ho-Jeong (Pharmaceutical Safety Bureau, Korea Food and Drug Administration)
Lee, Hwa-Jeong (College of Pharmacy, Ewha Womans University)
Koo, Young-Soon (College of Pharmacy, Ewha Womans University)
Publication Information
Journal of Pharmaceutical Investigation / v.38, no.4, 2008 , pp. 229-234 More about this Journal
Abstract
In the present study, chitosan-glycerophosphate sodium salt solution as a thermosensitive system (TSS) was used to formulate a temperature-sensitive drug delivery system (TSDDS) containing acetaminophen (AAP). The optimized TSS was prepared by measuring gelation temperature, gelation time and rheological properties of TSS. The optimized gelation temperature and time of TSS were $36^{\circ}C$ and 100 seconds, respectively. The viscosity of TSS was also suitable for maintaining gel structure at $37.2^{\circ}C$. The release profiles of TSDDS in PBS/pH 7.4 with various apparatuses and mass loss of TSDDS were investigated. The time required to release 50% of AAP from TSDDS ($t_{50%}$) was 120 min with the formation of pore on the surfaces, which was 2 times longer than that from AAP-chitosan gel. In addition, TSDDS was degraded approximately 80% within 4 hr and then degraded slowly for 20 hrs. In conclusion, AAP-TSS (TSDDS) formulated in this study might be suitable for some specific uses such as subcutaneous injection and rectal formulation.
Keywords
Temperature-sensitive drug delivery system; Chitosan; Acetaminophen;
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1 H. Struszcyk, D. Wawro, Niekraszewicz., C. J. In Brine, P. A. Sandford and J. P. Zikakis, Advances in chitin and chiosan, Elsevier Applied Science, London, pp. 580 (1991)
2 I. Henriksen, K. L. Green, J. D. Smart, G. Smistad and J. Karisen, Bioadhesion of hydrated chitosans; an in vitro study, Int. J. Pharm., 145, 231-240 (1996)   DOI   ScienceOn
3 D. S. Jones, Dynamic mechanical analysis of polymeric systems of pharmaceutical and biomedical significance, Int. J. Pharm., 179, 167-178 (1999)   DOI   ScienceOn
4 B. Jeong, Y. H. Bae and S. W. Kim, Drug release from biodegradable injectable thermosensitive hydrogel of PEGPLGA- PEG triblock copolymers, J. Control. Release, 63, 155-163 (2000)   DOI   ScienceOn
5 A. Chenite, C. Chaput, D. Wang, C. Combes, M. D. Buschmann, C. D. Hoemann, J. C. Leroux, B. L. Atkinson, F. Binette and A. Selmani, Novel injectable neutral solutions of chitosan form biodegradable gels in situ., Biomaterials, 21, 2155-2161, (2000)   DOI   ScienceOn
6 E. Ruel-Gariepy, A. Chenite, C. Chaput, S. Guirguis and J. C. Leroux, Characterization of thermosensitive chitosan gels for the sustained delivery of drugs, Int. J. Pharm., 203, 89- 98 (2000)   DOI   ScienceOn
7 J. Wu, Z. Su and G. Ma, Thermo-and pH-sensitive hydrogel composed of quaternized chitosan/glycerophosphate, Int. J. Pharm. 315, 1-11 (2006)   DOI   ScienceOn
8 Pharmaceutical Technical Procedures in European Pharmacopeia 3rd ed. Supplement, pp. 85-86 (2000)
9 N. V. Majeti and R. Kumar, A review of chitin and chitosan appliations, React. Funct. Polym., 46, 1-27 (2000)   DOI   ScienceOn
10 N. V. Majeti and K. Ravi, A review of chitin and chitosan applications, React. Funct. Polym.., 46, 1-27 (2000)   DOI   ScienceOn
11 H. Tomida, M. Shinohara, N. Kuwada and S. Kiryu, In vitro release characteristics of diclofenac and hydrocortisone from Pluronic F-127 gels, Acta. Pharm. Suec., 24, 263-272 (1987)
12 N. Avoyagi, N. Kaniwa and M. Uchiyama, Inter-laboratory reproducibility of release tests for suppositories, Drug. Devel. Ind. Pharm., 21, 176-183 (1996)
13 A. Bilia, V. Carelli, G. D. Colo and Nannipieri, E., In vitro evaluation of a pH-sensitive hydrogel for control of GI drug delivery from silicone-based matrices, Int. J. Pharm., 130, 83-92 (1996)   DOI   ScienceOn
14 R. Baker, In: Controlled Release of Bioactive Materials, Academic, New York, pp. 15 (1986)
15 P. He, S. S. Davis and L. Illum, In vitro evaluation of mucoadhesive properties of chitosan microspheres, Int. J. Pharm., 145, 231-240 (1992)
16 B. Jeong, Y. H. Bae and S. W. Kim, Drug release from biodegradable injectable thermosensitive hydrogel of PEGPLGA- PEG triblock copolymers, J. Control. Release, 63, 155-163 (2000)   DOI   ScienceOn
17 M. Malmsten and B. Lindman, Self-assembly in aqueous block copolymer solutions, Macromolecules, 25, 5440-5445 (1992)   DOI
18 A. Chenite, M. Buschmann, D. Wang, C. Chaput and N. Kandani, Rheological characterisation of thermogelling chitosan/glycerol-phosphate solutions, Carbohydr Polym., 46, 39-47 (2001)   DOI   ScienceOn
19 K. Edsman, J. Carlfos, R. Petersson, Rheological evaluation of poloxamer as an in situ gel for opthalmic use, Eur. J. Pharm. Sci., 6, 105-112 (1998)   DOI   ScienceOn
20 M. Yamazaki, S. Itoh, T. Yasui, S. C. Khee, H. Samon and K. Tanabe, Effect of temperature on the release of commercially available acetaminophen suppository, Yakuzaigaku, 54, 227-231 (1994)