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http://dx.doi.org/10.4333/KPS.2008.38.1.063

Preparation and Evaluation of Meloxicam-loaded Poly(D,L-lactic acid) Microspheres  

Im, Jong-Seob (College of Pharmacy, Yeungnam University)
Oh, Dong-Hoon (College of Pharmacy, Yeungnam University)
Li, Dong-Xun (College of Pharmacy, Yeungnam University)
Sung, Jung-Hoon (College of Pharmacy, Yeungnam University)
Yoo, Bong-Kyu (College of Pharmacy, Yeungnam University)
Kim, Jung-Ae (College of Pharmacy, Yeungnam University)
Woo, Jong-Soo (College of Pharmacy, Yeungnam University)
Lee, Yong-Bok (College of Pharmacy, Chonnam National University)
Kim, Se-Mi (College of Pharmacy, Chonnam National University)
Choi, Han-Gon (College of Pharmacy, Yeungnam University)
Yong, Chul-Soon (College of Pharmacy, Yeungnam University)
Publication Information
Journal of Pharmaceutical Investigation / v.38, no.1, 2008 , pp. 63-72 More about this Journal
Abstract
Meloxicam-loaded microspheres were prepared with poly(D,L-lactic acid)(PLA) by a solvent-emulsion evaporation method. The morphology, particle size, drug loading capacity, drug entrapment efficiency (EE) and release patterns of drug were investigated in vitro. Various batches of micro spheres with different size and drug content were obtained by changing the ratio of meloxicam to $PLA^{\circ}{\AE}s$ with different molecular weight, PLA concentration in the dispersed phase and stirring rate. Meloxicam crystals on microsphere surface, which were released rapidly and could act as a loading dose, were observed with increasing drug content. The release rate was increased with increase in drug contents and decrease in the molecular weight of PLA. Microspheres prepared with smaller molecular weight produced faster drug release rate. The release rate of meloxicam for long-acting injectable delivery system in vitro, which would aid in predicting in vivo release profile, could be controlled by properly optimizing various factors affecting characteristics of microspheres. Blood concentration-time profile of meloxicam after intramuscular injection of meloxicam-loaded microspheres in rabbits showed possibility of long term application of this system in clinical settings.
Keywords
Meloxicam; Poly(D,L-lactic acid); Microspheres; Injectable delivery system;
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