Browse > Article
http://dx.doi.org/10.4333/KPS.2007.37.6.365

Low-frequency Ultrasound Enhanced Transdermal Drug Delivery Across Rat Skin  

Lee, Hwa-Jin (College of Pharmacy, Kyungsung University)
Kim, Jong-Youl (Dept. of Automotive Engineering, Yangsan College)
Park, Jin-Nam (Chung-A Dermatology Clinic)
Shin, Young-Hee (College of Pharmacy, Kyungsung University)
Publication Information
Journal of Pharmaceutical Investigation / v.37, no.6, 2007 , pp. 365-368 More about this Journal
Abstract
The primary aim of this study was to investigate the enhancement effect of low-frequency ultrasound on skin permeation. In vitro permeation experiments were performed using Franz modified diffusion cells with ketoprofen as model drug. The effect of various ultrasound factors-ultrasound application mode (continuous mode and discontinuous mode), ultrasound intensity (0.26 $W/cm^2$, and 0.29 $W/cm^2$) and duty cycle (3%, 16%, 50%, and 83%) were studied. The highest permeation was observed at 0.29 $W/cm^2$ intensity, 50% duty cycle, and discontinuous mode. The result suggested the feasibility of low frequency ultrasound application for the phonophoretic transdermal drug delivery system.
Keywords
Phonophoretic; Low frequency ultrasound; Transdermal delivery; Ketoprofen;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
연도 인용수 순위
1 R.L. Bronaugh and H.I. Maibach, Percutaneous absorption. Marcel Dekker, New York, U.S.A., pp. 1-12 (1989)
2 H. Schaefer, A. Zesch and G. Stuttgen, Skin permeability. Springer-Verlag, New York, (1982)
3 C.S. Yong, J.D. Rhee and H.G. Choi, Factors affecting percutaneous absorption. J.S.B.R. 2, 49-67 (2000)
4 H.K. Tan, Y.S. Rhee, E.S. Park and S.C. Chi, Skin permeation of ketoprofen from lotion. J. Applied Pharmacology. 5, 357-363 (1997)   과학기술학회마을
5 K.H. Chung, Y.I. Kim and J.H. Yang, Phonophoretic delivery of piroxicam. J. Kor. Pharm. Sci. 32(4), 259-265 (2002)   과학기술학회마을
6 K.S. Song, Y.I. Kim and J.H. Yang, Transdermal delivery of triamcinolone acetonide gel by ultrasound. J. Kor. Pharm. Sci. 32(2), 87-93 (2002)
7 S. Mitragotri and J. Kost, Low-frequency sonophoresis a review. Advanced Drug Delivery Reviews. 56, 589-601 (2004)   DOI   ScienceOn
8 J.E. Riviere and M.C. Heit, Electrically-assisted transdermal drug delivery. Pharm. Res. 14, 687-697 (1997)   DOI   ScienceOn
9 R.R. Burnette, Iontophoresis in transdermal drug delivery. Hadgraft, J. and Cuy, R. H. (eds.). Marcel Dekker, New York, 247-291 (1989)
10 P. Tyle and P. Agrawala, Drug delivery by phonophoresis. Pharm. Res. 6, 355-359 (1989)   DOI
11 N.B. Smith, S. Lee, E. Maione, R.B. Roy, S. McElligott and K.K. Shung, Ultrasound-mediated transdermal transport of insulin in vitro through human skin using novel transducer designs. Ultrasound in Med & Biol. 29(2), 311-317 (2003)   DOI   ScienceOn
12 W.L. Nyborg, Ultrasonic micro streaming and relayed phenomena. Br. J. Cancer. 45(5), 156-160 (1982)
13 E.L. Nussbaum, Therapeutic ultrasound. Physical Agents Theory and Practice for The Physical Therapist Assistant, Yeongmun Publishing Company, Seoul, pp. 95-102 (1996)
14 Y. Tashiro, S. Shichibe, Y. Kato, E. Hayakawa and K. Itoh, Effect of lipophilicity on in vivo iontophoretic delivery. I. NSAIDs. Biol. Pharm. Bull. 24(3), 278-283 (2001)   DOI   ScienceOn
15 G. Merin, Y.N. Kalia, M.B. Delgado-Charro, R.O. Potts and R.H. Guy, Frequency and thermal effects on the enhancement of transdermal transport by sonophoresis. J. Controlled Release. 88, 85-94 (2003)   DOI   ScienceOn
16 J.Y. Fang, C.L. Fang, K.C. Sung and H.Y. Chen, Effect of low-frequency ultrasound on the in vitro percutaneous absorption of clobetasol 17-propionate. Int. J. Pharm. 191, 33-42 (1999)   DOI   ScienceOn
17 S. Mitragotri, J. Farrell, H. Tang, T. Terahara, J. Kost and R. Langer, Determination of threshold energy dose for ultrasound-induced transdermal drug transport. J. Controlled Release. 63, 41-52 (2000)   DOI   ScienceOn
18 T. Terahara, S. Mitragotri, J. Kost and R. Langer, Dependence of low-frequency sonophoresis on ultrasound parameters; distance of the hom and intensity. Int. J. Pharm. 235, 35-42 (2002)   DOI   ScienceOn
19 A. Boucaud, L. Machet, B. Arbeille, M.C. Machet, M. Soumac, A.Mavon, F. Patat and L. Vaillant, In vitro study of low-frequency ultrasound-enhanced transdermal transport of fentanyl and caffeine across human and hairless rat skin. Int. J. Pharm. 228, 69-77 (2001)   DOI   ScienceOn
20 S. Mitragotri, D. Blankschtein and R. Langer, Transdermal drug delivery using low-frequency sonophoresis. Pharm. Res. 13(3), 411-420 (1996)   DOI