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http://dx.doi.org/10.4333/KPS.2007.37.2.101

Formulation of Sustained Release Granule for Venlafaxine-HCl Using Water-Insoluble Polymer  

Park, Ji-Seon (Laboratory of Industrial Pharmacy, Chungnam National University)
Seo, Jin-A (Department of Information & Biomaterials, Hannam University)
Jeong, Sang-Young (Laboratory of Industrial Pharmacy, Chungnam National University)
Yuk, Soon-Hong (Department of Information & Biomaterials, Hannam University)
Shin, Byung-Cheol (Nanobiomaterials Laboratory, Korea Research Institute of Chemical Technology)
Hwang, Sung-Joo (Laboratory of Industrial Pharmacy, Chungnam National University)
Cho, Sun-Hang (Laboratory of Industrial Pharmacy, Chungnam National University)
Publication Information
Journal of Pharmaceutical Investigation / v.37, no.2, 2007 , pp. 101-106 More about this Journal
Abstract
Venlafaxine, 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl] cyclohexanol hydrochloride is a novel, nontricyclic antidepressant. venlafaxine is a unique antidepressant that differs structurally from other currently available. The aim ot the study was to formulate sustained-release venlafaxine granules and assess their formulation variables. It consists of two layers, venlafaxine drug layer and sustained release coating layer and manufactured by fluidized bed process. The sustained release of drug could be increased by double-control rising various components in venlafaxine drug layer and sustained-release layer. The drug-containing granules were coated with cellulose acetate, cetyl alcohol and Eudragit RS along with plastisizer such as dibuthyl sebacate as an nano-pore former The release oi venlafaxine depended on the type of Eudragit such as RS, and RL used in the formulation of controlled release layer. These results obtained clearly suggest that the sustained release oral delivery system for venlafaxine could be designed with satisfying drug release profile approved.
Keywords
Venlafaxine hydrochloride; Water-insoluble polymer; Fluid-bed coating;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
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