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http://dx.doi.org/10.4333/KPS.2006.36.1.011

Preparation and Release Characterization of Osmotic Granule Nifedipine Delivery System  

Jeong, Sung-Chan (Department of Polymer Engineerng, Pukyung National University)
Cho, Young-Ho (Department of Polymer.Nano Science and Technology, Chonbuk National University)
Lee, Soo-Young (Department of Polymer Engineerng, Pukyung National University)
Lee, Bong (Department of Polymer Engineerng, Pukyung National University)
Kim, Moon-Suk (Nanobiomaterials Laboratory, Korea Research Institute of Chemical Technology)
Kang, Gil-Son (Department of Polymer.Nano Science and Technology, Chonbuk National University)
Lee, Hai-Bang (Nanobiomaterals Laboratory, Korea Research Institute of Chemical Technology)
Publication Information
Journal of Pharmaceutical Investigation / v.36, no.1, 2006 , pp. 11-17 More about this Journal
Abstract
The objective of this study was to confirm the effect of the type of dissolution media and paddle speed on nifedipine (ND) release profile from osmotic granule and the storage stability. Osmotic granule was manufactured by fluidized bed coating method. At each coating step, morphology of osmotic granule was differed. The size of osmotic granule was $750\;{\mu}m$ at 3 wt% membrane thickness. ND release was changed in diverse dissolution media, paddle speed. ND release is governed by not only osmotic pressure but diffusion from osmotic granule. ND release from osmotic granule decreased as storage period increased. These may be caused by liquid excipient which has low molecular weight. Storage stability of osmotic granule could be improved by removing liquid excipient from semipermeable membrane.
Keywords
Nifedipine; Osmotic granule; Fluidized bed coating; Drug release profile; Storage stability;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
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