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http://dx.doi.org/10.4333/KPS.2005.35.2.107

Physicochemical Characterization of Clotrimazole-Loaded Solid Suppository Using Poloxamer and Propylene Glycol  

Xuan, Jing-Ji (College of Pharmacy, Yeungnam University)
Oh, Yu-Kyoung (College of Pharmacy, Yeungnam University)
Kim, Jung-Ae (College of Pharmacy, Yeungnam University)
Gong, Kyung-Hwan (College of Pharmacy, Yeungnam University)
Kim, Ji-Hyun (College of Pharmacy, Yeungnam University)
Yang, Joon-Ho (College of Pharmacy, Yeungnam University)
Bae, Myung-Soo (College of Pharmacy, Yeungnam University)
Kim, Ho-Dong (College of Pharmacy, Yeungnam University)
Rhee, Jong-Dal (College of Pharmacy, Yeungnam University)
Chang, Hyeun-Wook (College of Pharmacy, Yeungnam University)
Yong, Chul-Soon (Department of Microbiology, College of Medicine, Pochon DHA University)
Choi, Han-Gon (Department of Microbiology, College of Medicine, Pochon DHA University)
Publication Information
Journal of Pharmaceutical Investigation / v.35, no.2, 2005 , pp. 107-110 More about this Journal
Abstract
To develop a clotrimazole-loaded solid suppository with poloxamer and propylene glycol, the melting points of various formulations composed of poloxamer 188 (P 188) and propylene glycol were investigated. The dissolution study of clotrimazole delivered by the suppository composed of P 188 and propylene glycol was performed. The mixtures composed of P 188 and propylene glycol were homogeneous. Propylene glycol affected the melting points of poloxamer mixtures. In particular, the mixture [P 188/propylene glycol (70/30%)] with the melting point of about $32^{\circ}C$ was a solid form at room temperature and instantly melted at physiological temperature. Furthermore, propylene glycol affected greatly the dissolution rates of clotrimazole from the suppository. Dissolution mechanism analysis showed the dissolution of clotrimazole was proportional to the time. Our results indicated that the solid suppository with P 188 and propylene glycol would be a candidate of rectal dosage form for clotrimazole.
Keywords
clotrimazole; propylene glycol; poloxamer 188; suppository; melting point;
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Times Cited By KSCI : 1  (Citation Analysis)
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