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http://dx.doi.org/10.4333/KPS.2005.35.1.007

Skin Permeation and Crosslinking with Biological Tissue of the Hydrolyzed Products of Gardeniae Fructus Extract  

Yang, Jae-Heon (College of Pharmacy, Woosuk University)
Lee, Nam-Hee (College of Pharmacy, Woosuk University)
Publication Information
Journal of Pharmaceutical Investigation / v.35, no.1, 2005 , pp. 7-16 More about this Journal
Abstract
Gardeniae Fructus is consisted of geniposide and it's derivatives. For the purpose of treatment of skin disease, geniposide and hydrolyzed products (HP) of Gardeniae Fructus were studied on skin permeation and cross1inking with biological tissue. The hydrolyzed products (HP) and active ingredients of Gardeniae Fructus were identified and investigated about skin permeability. Genipin has provided low cytotoxic cross1inking reagents and formed stable and biocompatible crosslinked products. The permeation enhancing effects of geniposide and genipin under the hydrolyzed products of cream and hydrogel preparations were tested using Franz type diffusion cell and the skin of hairless mouse. The remaining proportions of geniposide and genipin were measured in the hydrolyzed products of cream and hydrogel preparations. The crosslinking of epidermic and endodermic tissue with genipin under the hydrolyzed prodcuts of cream and hydrogel preparation was observed using light microscopy. Increased absorption ratio of the skin of hairless mouse about genipin was higher than that of geniposide. Loads at break, tensile strengths and skin permeation rate of the hydrolyzed products (HP) of cream and hydrogel preparations were higher than the nonhydrolyzed products (NHP). The hydrolyzed products (HP) of cream and hydrogel of Gardeniae Fructus Extracts were proper preparations and crosslinking agents to increase the transdermal absorption with epidermic and endodermic tissue.
Keywords
Geniposide; Genipin; Skin permeation; Crosslinking;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
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