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http://dx.doi.org/10.4333/KPS.2004.34.6.477

Prevention of Postsurgical Adhesions with a Mixed Gel of Sodium Carboxymethyl Cellulose and Gellan Gum in the Rat  

Kwon, Yun-Hwan (NRL of Pharmaceutical Technology, College of Pharmacy, Chungnam National University)
Lee, Si-Beum (NRL of Pharmaceutical Technology, College of Pharmacy, Chungnam National University)
Lee, Jong-Goen (Institute for R&D, Amitie Co., LTD.)
Park, Yong-Deuk (Dept. of Pet Science, Youngdong University)
Park, Jeong-Sook (NRL of Pharmaceutical Technology, College of Pharmacy, Chungnam National University)
Hwang, Sung-Joo (NRL of Pharmaceutical Technology, College of Pharmacy, Chungnam National University)
Publication Information
Journal of Pharmaceutical Investigation / v.34, no.6, 2004 , pp. 477-482 More about this Journal
Abstract
The aim of the present study was to investigate the efficacy of a mixed gel formulation composed of sodium carboxymethyl cellulose and gellan gum (Na-CMC gel) for the prevention of adhesions after laminectomy. The anti-adhesive effect of the Na-CMC gel was tested in a controlled randomized study using an animal model of lumbar laminectomy. The animals (60 female Sprague-Dawley rats) were randomly allocated into two treatment groups to receive the Na-CMC gel on the injured area or no gel (control). The incidence of adhesions and their grade were blindly evaluated at 4, 8 and 12 weeks after surgery. The amount of scar tissue and tenacity were grossly reduced by the Na-CMC gel at postoperative 4, 8, and 12 weeks. The mean adhesion scores were 0.75, 1.25, and 1.38 at 4, 8, and 12 weeks in the gel-treated group, respectively. No significant inflammatory reaction was observed and the healing of wound was not affected by the Na-CMC gel. The Na-CMC gel reduced the amount of scar formation and tenacity in rat laminectomy model without affecting the healing of operation wound and other complications. Therefore, the Na-CMC gel may be the potential to prevent postsurgical adhesions in clinical state.
Keywords
Antiadhesion; Sodium arboxymethyl cellulose; Gellan gum; Laminectomy;
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