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http://dx.doi.org/10.4333/KPS.2004.34.4.289

Effect of Types and Mixing Ratios of Water-Soluble Polymers on In Vitro Release Profile of Sold Dispersion for Acyclovir  

Ahn, Yong-San (Department of Polymer.Nano Science and Technology, Chonbuk National University)
Lee, Ha-Young (Department of Advanced Organic Materials Engineering, Chonbuk National University)
Hong, Keum-Duck (Department of Polymer.Nano Science and Technology, Chonbuk National University)
Jung, Sung-Beum (Department of Polymer.Nano Science and Technology, Chonbuk National University)
Cho, Sun-Hang (Nanobiomaterials Laboratory, Korea Research Institute of Chemical Technology)
Rhee, John M. (Department of Polymer.Nano Science and Technology, Chonbuk National University)
Lee, Hai-Bang (Nanobiomaterials Laboratory, Korea Research Institute of Chemical Technology)
Khang, Gil-Son (Department of Polymer.Nano Science and Technology, Chonbuk National University)
Publication Information
Journal of Pharmaceutical Investigation / v.34, no.4, 2004 , pp. 289-297 More about this Journal
Abstract
Acyclovir (ACV) is one of the most effective and selective agents against viruses of the herpes group. Because of low solubility, bioavailability of ACV has shown below 30% with oral dosage form. In our previous study, we reported that the fabrication of solid dispersion of ACV was possible and the solid dispersion of ACV and PVP was the most useful in all samples. In this study, we examined the effect of mixture ratio of polymers (PEG and PVP) to ACV. Solubility of ACV was dramatically increased up to 25 mg/ml in $80^{\circ}C$ distilled water. So water was used as a solvent to eliminate problem of residual solvent. Spray drying method was used for the solid dispersion of ACV as solvent extraction. Different scanning calorimeter was used to check degradation of drug. Polymer carriers were PEG 6,000 and PVP. In summary, ACV-PVP (1:3) showed the best solubility in distilled water.
Keywords
Acyclovir; Solid dispersion; Water; PEG; PVp;
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