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http://dx.doi.org/10.4333/KPS.2004.34.3.169

Preparation and In Vitro Test of Sold Dispersion using Acyclovir and Water Soluble Polymer  

Ahn, Yong-San (Department of Polymer.Nano Science and Technology Chonbuk National University)
Lee, Ha-Young (Department of Advanced Organic Materials Engineering, Chonbuk National University)
Hong, Keum-Duck (Department of Polymer.Nano Science and Technology Chonbuk National University)
Jung, Sung-Beum (Department of Polymer.Nano Science and Technology Chonbuk National University)
Cho, Sun-Hang (Nanobiomaterials Laboratory Korea Research Institute of Chemical Technology)
Rhee, John-Moon (Department of Polymer.Nano Science and Technology Chonbuk National University)
Lee, Hai-Bang (Nanobiomaterials Laboratory Korea Research Institute of Chemical Technology)
Khang, Gil-Son (Department of Polymer.Nano Science and Technology Chonbuk National University)
Publication Information
Journal of Pharmaceutical Investigation / v.34, no.3, 2004 , pp. 169-176 More about this Journal
Abstract
Acyclovir(ACV) is an important antiviral drug used extensively against infections caused by herpes viruses, especially herpes simplex and varicella zoster. Because of high crystallinity and large particle size, solubility of intact ACV is very low in water(1.3 mg/ml). The goal of this work is to enhance the solubility of ACV. To make solid dispersion, Polyethyleneglycol, Hydroxyprophylmethylcelluose and Polyvinylpyrrolidone were used as polymer carriers in this work. Polymer carriers and drug were dissolved in acetic acid. And then spray drying method and freeze drying method were used as solvent extraction. Morphology, crystallization and functional group were characterized using SEM, XRD and FT-IR. The result of in vitro test showed the sample using PVP as polymer carrier had higher dissolution rate(up to 466%) than intact ACV.
Keywords
Acyclovir; Sold dispersion; Polymer carriers;
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