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http://dx.doi.org/10.4333/KPS.2004.34.1.035

Preparation and Characterization of Liquefied Ibuprofen Using Self-Microemulsion Drug Delivery System (SMEDDS)  

Ahn, Yong-San (Department of Polymer.Nano Science and Technology, Chonbuk National University)
Song, Ji-Hee (Department of Polymer.Nano Science and Technology, Chonbuk National University)
Kang, Bok-Ki (Department of Polymer.Nano Science and Technology, Chonbuk National University)
Kim, Moon-Suk (Nanobiomaterials Laboratory, Korea Research Institute of Chemical Technology)
Cho, Sun-Hang (Nanobiomaterials Laboratory, Korea Research Institute of Chemical Technology)
Rhee, John-M. (Department of Polymer.Nano Science and Technology, Chonbuk National University)
Lee, Hai-Bang (Nanobiomaterials Laboratory, Korea Research Institute of Chemical Technology)
Khang, Gil-Son (Department of Polymer.Nano Science and Technology, Chonbuk National University)
Publication Information
Journal of Pharmaceutical Investigation / v.34, no.1, 2004 , pp. 35-42 More about this Journal
Abstract
Ibuprofen (IBU), is a non-steroidal anti-inflammatory drug, used to treat rheumatoid arthritis, removal of fever and mild to moderate pain. Because of small dosage and very low accumulation in the body, IBU has been used to heal children's fever. However, IBU was very low solubility in a low pH and water (in water $0.03{\sim}2.5$ mg/ml). A nanoemulsion containing IBU by means of self-microemulsion drug delver system (SMEDDS) was prepared in order to enhance the solubility of IBU. The SMEDDS was composed of cosurfactant, oil and surfactant The solubility of IBU in various components such as cosurfactant, oil and surfactant was examined. $Carbitol^{\circledR}\;(386.99{\pm}20.5\;mg/ml)$ as a cosurfactant, $Labrafil^{\circledR}$　 M1944CS $(90.16{\pm}1.60mg/ml)$ as an oil and $Cremopher^{\circledR}$　 RH-40 $(239.01{\pm}2.8\;mg/ml)$ as a surfactant were used in this study for preparing SMEDDS. Optimized formulation of SMEDDS was obtained by phase diagram which express the section of nanoemulsion formation. The SMEDDS containing IBU had higher dissolution rate than conventional IBU sirups. Thus the SMEDDS was a potential candidate of stable conventional and effective oral dosage form for IBU.
Keywords
Ibuprofen; SMEDDS; Phase diagram; Cosurfactant; Surfactant; Oil;
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