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http://dx.doi.org/10.4333/KPS.2003.33.3.157

Transport Characteristics and Screening of Penetration Enhancer through Buccal Mucosa of Butorphanol Tartrate from [P(AA-co-PEGMM)] Copolymer Films  

Kim, Joun-Sik (College of Pharmacy, Chungbuk National University)
Park, Jeong-Sook (College of Pharmacy, Chungbuk National University)
Jeong, Yeon-Bok (College of Pharmacy, Chungbuk National University)
Han, Kun (College of Pharmacy, Chungbuk National University)
Publication Information
Journal of Pharmaceutical Investigation / v.33, no.3, 2003 , pp. 157-162 More about this Journal
Abstract
The feasibility of [P(AA-co-PEGMM)] film as a buccal mucoadhesive patch was previously reported by estimating mucoadhesiveness and release characteristics. To find a rational penetration enhancer of [P(AA-co-PEGMM)] film containing butorphanol tartrate (Bt), penetration of Bt from [P(AA-co-PEGMM)] film which contained various additives was estimated by measuring its flux, Papp and lag tme in in vitro buccal membrane of porcine. EDTA showed almost no increase of Bt permeability, wherease SGC, STDHF and SLS increased the permeability of Bt with the order of SGC > STDHF > SLS. The rational additive concentration of SGC was 4% and its Papp and lag time were $1.93{\times}10^{-4}{\pm}4.21{\times}10^{-6},\;126.60{\pm}21.88min\;(control\;:\;Papp\;0.45{\times}10^{-4};\;lag\;time\;211.01{\pm}16.77\;min)$, respectively.
Keywords
Butorphanol tartrate; Buccal mucoadhesive film; Penetration enhancer; Sodium glycocholate;
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