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http://dx.doi.org/10.4333/KPS.2002.32.4.277

The Effect of Sodium Alginate Coating on the Storage Stability and Dissolution Rate of Enteric Coated Lansoprazole  

Kim, Jung-Hoon (Department of Advanced Organic Materials Engineering, Chonbuk National University)
Oh, Jung-Min (Department of Advanced Organic Materials Engineering, Chonbuk National University)
Khang, Gil-Son (Department of Advanced Organic Materials Engineering, Chonbuk National University)
Jeong, Je-Kyo (Research Center, Samchundang Pharm. Co. Ltd.)
Lee, Jung-Sik (Research Center, Samchundang Pharm. Co. Ltd.)
Jeung, Sang-Young (Biomaterials Laboratory, Korea Research Institute of Chemical Technology)
Lee, Hai-Bang (Biomaterials Laboratory, Korea Research Institute of Chemical Technology)
Publication Information
Journal of Pharmaceutical Investigation / v.32, no.4, 2002 , pp. 277-284 More about this Journal
Abstract
Lansoprazole, pharmaceutics for acid-related diseases, is unstable in low pH environments and generally coated with enteric polymer to obtain gastroresistance in stomach. Because its storage stability is influenced by acidic substitutes of enteric polymer, alkaline chemicals wεre generally addεd to dosage form as a stabilizer. In this experience, we coated lansoprazole bead with sodium alginate and evaluated the effect of bead size and sodium alginate coating on the storage stability and dissolution profile of lansoprazole. Sodium alginate solution containing lansoprazole was sprayed as a droplet into 3% (w/v) $CaCl_2$ solution and the resultant bead was coated with starch, sodium alginate, and hydroxypropyl methylcellulose phthalate. The content of lansoprazole granule not coated with sodium alginate decreased to 57.96% of initial content when stored at a severe condition for 4 weeks, but that of lansoprazole granule coated with sodium alginate before enteric coating decreased little and as the thickness of sodium alginate film increased, the content of bead didn't decreased for 4 weeks. Sodium alginate film also improved the gastroresistance without much influencing the maximum dissolution rate.
Keywords
Lansoprazole; Sodium Alginate; Enteric Coating; Bead Size; Storage Stability; Dissolution Profile; Gastroresistance;
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